BATCH PRODUCTION OF PHARMACEUTICAL GRANULATIONS IN A FLUIDIZED BED .1. EFFECTS OF PROCESS VARIABLES ON PHYSICAL PROPERTIES OF FINAL GRANULATION
BATCH PRODUCTION OF PHARMACEUTICAL GRANULATIONS IN A FLUIDIZED BED .1. EFFECTS OF PROCESS VARIABLES ON PHYSICAL PROPERTIES OF FINAL GRANULATION
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DOI：
10.1002/jps.2600601224
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发表时间：
1971-01-01
影响因子：
3.8
通讯作者：
GLOOR, WT
中科院分区：
文献类型：
--
作者：
DAVIES, WL;GLOOR, WT
该研究涉及与流化床造粒技术相关的工艺变量对最终造粒物理性质的影响。研究的工艺变量包括粘合剂溶液添加速率、二元喷嘴的气压、造粒周期期间的入口空气温度以及二元喷嘴相对于流化固体的位置。当添加到粉末流化床的粘合剂水溶液的速率增加时，溶液润湿和渗透固体的能力增强，导致：(a)更大的平均颗粒尺寸，(b)更不易碎的颗粒，(c)更流动的颗粒，和(d)降低的颗粒松密度。类似的结果也可归因于粘合剂溶液效率的提高，在造粒周期期间，随着二元喷嘴气压或入口空气温度的降低而发生。二元喷嘴相对于流化粉末的位置对平均颗粒尺寸和颗粒脆碎度具有显着影响。然而，对造粒流动特性和膨松度的影响很小。
The investigation concerns the effects of process variables associated with the fluidized bed granulation technique on the physical properties of the final granulation. The process variables investigated include binder solution addition rate, air pressure to the binary nozzle, inlet air temperature during the granulation cycle, and binary nozzle position with respect to the fluidized solids. When the rate at which the aqueous binder solution added to the fluidized bed of powders was increased, the ability of the solution to wet and penetrate the solids was enhanced, resulting in: (a) a larger average granule size, (b) a less friable granulation, (c) a more fluid granulation, and (d) a decreased granulation bulkiness. Similar results, also traceable to enhanced binder solution efficiency, occurred with a decrease either in the binary nozzle air pressure or in the inlet air temperature during the granulation cycle. The position of the binary nozzle with respect to the fluidized powders had significant effects upon the average granule size and granule friability. The effects upon the granulation flow properties and bulkiness, however, were slight.