Correlation of sonographic features of invasive ductal mammary carcinoma with age, tumor grade, and hormone-receptor status.
Correlation of sonographic features of invasive ductal mammary carcinoma with age, tumor grade, and hormone-receptor status.
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DOI：
10.1002/jcu.21990
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Cunningham JE
中科院分区：
文献类型：
--
作者：
Aho M;Irshad A;Ackerman SJ;Lewis M;Leddy R;Pope TL;Campbell AS;Cluver A;Wolf BJ;Cunningham JE
确定浸润性导管癌（IDC）的超声表现是否与患者年龄、肿瘤组织学分级和激素受体状态相关。根据BI-RADS后方声学表现、肿瘤边缘和回声的标准，回顾性评估了101例连续超声检查发现的IDC的超声特征。超声特征和肿瘤特征之间的关联进行了统计学评估，并注意患者的年龄。与后部声学表现不变的IDC相比，有阴影的IDC更可能是低组织学分级（比值比[OR] = 5.00; p < 0.05）和雌激素受体（ER）阳性（OR = 10.00; p < 0.05）。相反，后方增强与ER阴性状态相关（OR = 4.45; p < 0.01），特别是在年龄小于60岁的患者中（OR = 5.36，p < 0.05）。局限性肿瘤多为高级别，尤其是老年妇女（p < 0.01），且激素受体阴性，与年龄组无关。在老年妇女中，混合回声的肿瘤倾向于高级别和孕激素受体阴性（p值< 0.05）。所有肿瘤后方阴影边界不清，97%的肿瘤ER阳性。超声特征与肿瘤分级和激素受体状态显著相关，根据患者年龄存在一些差异。具体而言，后方阴影的存在与较低的组织学分级和ER阳性状态相关，尤其是在老年患者中。相反，我们发现后部声学增强更常见于ER阴性状态，尤其是在年轻患者中。
To determine whether presenting sonographic features of invasive ductal carcinomas (IDC) are associated with patient age, tumor histologic grade, and hormonal receptor status. Sonographic features of 101 consecutive cases of IDC seen at ultrasound were retrospectively assessed based on the BI-RADS criteria of posterior acoustic appearance, tumor margins, and echogenicity. Associations between sonographic features and tumor characteristics were statistically evaluated with attention to patient age. IDC with shadowing compared with unchanged posterior acoustic appearance were significantly more likely to be of low histologic grade (Odds Ratio [OR] = 5.00; p < 0.05) and estrogen receptor (ER) -positive (OR = 10.00; p < 0.05). Conversely, posterior enhancement was associated with ER-negative status (OR = 4.45; p < 0.01), particularly among patients younger than 60 years of age (OR = 5.36, p < 0.05). Circumscribed tumors were more often high grade, particularly among older women (p < 0.01), and hormone receptor--negative regardless of age group. Among older women, tumors with mixed echogenicity tended to be high grade and progesterone receptor--negative (p values < 0.05). Noncircumscribed borders were observed for all tumors with posterior shadowing, and 97% of such tumors were also ER positive. Sonographic features were significantly associated with tumor grade and hormone receptor status, with some differences based on patient age. Specifically, the presence of posterior shadowing was associated with lower histologic grade and ER-positive status, especially in older patients. In contrast, we found that posterior acoustic enhancement was more commonly associated with ER-negative status, especially in younger patients.