Relationship between clinical and neuropsychological characteristics in child and adolescent first degree relatives of subjects with schizophrenia
Relationship between clinical and neuropsychological characteristics in child and adolescent first degree relatives of subjects with schizophrenia
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DOI：
10.1016/j.schres.2009.09.001
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发表时间：
2010-02-01
影响因子：
4.5
通讯作者：
Castro-Fornieles, Josefina
中科院分区：
文献类型：
--
作者：
de la Serna, Elena;Baeza, Inmaculada;Castro-Fornieles, Josefina
简介：研究表明，精神分裂症患者亲属的精神病理学和认知困难发生率高于一般人群。本研究旨在分析精神分裂症高遗传风险儿童和青少年的临床和神经心理特征之间的关系。方法：研究对象为26名被诊断为精神分裂症受试者（高危[HR]组）的儿童和青少年一级亲属，以及20名其父母和兄弟姐妹不符合任何精神障碍的DSM-IV标准的对照。这两组患者的年龄、性别和社会经济状况相匹配，所有参与者均完成了临床和神经心理学评估。 结果：HR 儿童中，42.3% 被诊断患有一种或多种 DSM-IV 轴 I 精神疾病。最常见的诊断是注意力缺陷/多动障碍（ADHD）（34.6%）和广泛性焦虑症（3.8%）：HR儿童和对照组在前驱症状、行为问题和病前调整以及大多数智力分量表、工作记忆和逻辑记忆方面存在显着差异。当分析有ADD的HR（HR-ADD）、无ADD的HR（HR-NADD）和对照组之间的差异时，发现HR-ADD在前驱症状、行为问题和病前调整的临床量表上的得分显着高于HR-NADD或对照组。 HR-ADD与HR-NADD的认知领域无显着差异，但HR-ADD与对照组之间以及HR-NADD与对照组之间在语言理解指数、知觉推理指数、工作记忆指数和GAL方面存在显着差异。结论：与对照组相比，HR儿童表现出更多的临床症状和认知异常。患有 ADD 的 HR 儿童的临床症状比不患有 ADD 的 HR 儿童更严重，但在认知异常方面没有差异。两个 HR 组似乎在神经心理学表现上都有相似的缺陷。 (C) 2009 Elsevier B.V. 保留所有权利。
Introduction: Studies have shown higher rates of psychopathology and cognitive difficulties among relatives of schizophrenia patients than among the general population. This study aimed to analyze the relationship between clinical and neuropsychological characteristics in children and adolescents at high genetic risk for schizophrenia.Methods: Participants were 26 children and adolescent first-degree relatives of subjects diagnosed with schizophrenia (high-risk [HR] group) and 20 controls whose parents and siblings did not meet DSM-IV criteria for any psychotic disorder. These two groups were matched by age, sex and socio-economic status and clinical and neuropsychological assessments were completed by all participants.Results: Among HR children 42.3% were diagnosed with one or more DSM-IV axis I psychiatric disorders. The most common diagnoses were attention deficit/hyperactivity disorder (ADHD) (34.6%) and generalized anxiety disorder (3.8%): There were significant differences between HR children and controls with respect to prodromal symptoms, behavioral problems and premorbid adjustment, as well as on the majority of intelligence subscales, working memory and logical memory. When differences between HR with ADD (HR-ADD), HR without ADD (HR-NADD) and controls were analyzed, significantly higher scores on clinical scales of prodromal symptoms, behavioral problems and premorbid adjustment were found in HR-ADD than in HR-NADD or controls. There were no significant differences in cognitive domains between HR-ADD and HR-NADD, but there were between HR-ADD and controls and between HR-NADD and controls on the Verbal Comprehension Index, Perceptual Reasoning Index, Working Memory Index and GAL.Conclusions: Compared to controls, HR children showed more clinical symptoms and cognitive abnormalities. HR children with ADD had worse clinical symptoms than did HR without ADD, although there were no differences in terms of cognitive abnormalities. Both HR groups seem to have similar deficits in neuropsychological performance. (C) 2009 Elsevier B.V. All rights reserved.