Beam hardening artifacts in micro-computed tomography scanning can be reduced by X-ray beam filtration and the resulting images can be used to accurately measure BMD.
Beam hardening artifacts in micro-computed tomography scanning can be reduced by X-ray beam filtration and the resulting images can be used to accurately measure BMD.
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DOI：
10.1016/j.bone.2009.07.078
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发表时间：
2009-12
期刊：
影响因子：
4.1
通讯作者：
Goldstein, Steven A.
中科院分区：
文献类型：
--
作者：
Meganck, Jeffrey A.;Kozloff, Kenneth M.;Thornton, Michael M.;Broski, Stephen M.;Goldstein, Steven A.
骨密度(BMD)测量在许多研究骨骼完整性的研究中是至关重要的。对于临床前研究，微型计算机断层扫描(μCT)已成为这些研究中必不可少的工具。然而，直接从μCT图像测量骨密度的能力可能会受到图像中射束硬化等伪影的影响。这项由三部分组成的研究旨在了解图像采集过程如何影响结果的骨密度测量，并验证骨密度测量的准确性。在这项研究的第一部分，研究了射束硬化诱导的拔罐伪影对骨密度测量的影响。在本研究的第二部分中，研究了X射线路径中的骨骼数目和扫描过程中的采样过程。在这项研究的第三部分，将基于μCT的骨密度测量结果与骨灰重量进行比较，以验证测量的准确性。结果表明，在研究矿化组织和影响矿物密度测量的研究中，可能会出现高达32.6%的射束硬化伪影。波束过滤可以用来使这些伪影最小化。结果还表明，对于小鼠股骨，扫描设置会影响皮质骨和松质骨的密度测量以及松质骨的形态测量。最后，当使用将所有这些伪影降至最低的扫描设置时，基于μCT的测量结果与灰重测量结果相关性良好(排除空气时R2=0.983)，表明μCT可以成为小鼠骨密度测量的准确工具。
Bone mineral density (BMD) measurements are critical in many research studies investigating skeletal integrity. For preclinical research, micro-computed tomography (μCT) has become an essential tool in these studies. However, the ability to measure the BMD, directly from μCT images can be biased by artifacts such as beam hardening, in the image. This three-part study was designed to understand how the image acquisition process can affect the resulting BMD measurements and to verify that the BMD measurements are accurate. In the first part of this study, the effect of beam hardening-induced cupping artifacts on BMD measurements was examined. In the second part of this study, the number of bones in the X-ray path and the sampling process during scanning was examined. In the third part of this study, μCT-based BMD measurements were compared with ash weights to verify the accuracy of the measurements. The results indicate that beam hardening artifacts of up to 32.6% can occur in sample sizes of interest in studies investigating mineralized tissue and affect mineral density measurements. Beam filtration can be used to minimize these artifacts. The results also indicate that, for murine femora, the scan setup can impact densitometry measurements for both cortical and trabecular bone and morphologic measurements of trabecular bone. Last, when a scan setup that minimized all of these artifacts was used, the μCT based measurements correlated used well with ash weight measurements (R2 = 0.983 when air was excluded), indicating that μCT can be an accurate tool for murine bone densitometry.
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