Principles underlying sensory map topography in primary visual cortex.
Principles underlying sensory map topography in primary visual cortex.
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DOI：
10.1038/nature17936
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发表时间：
2016-05-05
期刊：
影响因子：
64.8
通讯作者：
Alonso JM
中科院分区：
文献类型：
--
作者：
Kremkow J;Jin J;Wang Y;Alonso JM
初级视皮层包含视觉场景的详细地图，其根据包括空间位置、眼优势和方向的多个刺激维度来表示。空间定位图和眼优势图来源于丘脑轴突在皮层的空间排列。然而，其他地图的来源仍然不清楚。在这里，我们表明，皮质地图的方向，方向和视网膜视差都强烈相关的光（ON）和暗（OFF）刺激的空间位置的组织，我们显示的组织是OFF主导的，OFF为中心的，并运行正交的眼优势列。由于这种ON/OFF组织起源于视皮层中ON和OFF丘脑传入神经的聚类，我们得出结论，皮质地形图的所有主要特征，包括方向，方向和视网膜视差，遵循一个共同的组织原则，即在相邻的皮质区域中以相似的retinotopy和ON/OFF极性排列丘脑轴突。
The primary visual cortex contains a detailed map of the visual scene, which is represented according to multiple stimulus dimensions including spatial location, ocular dominance and orientation. The maps for spatial location and ocular dominance originate from the spatial arrangement of thalamic axons in cortex. However, the origin of the other maps remains unclear. Here we demonstrate that the cortical maps for orientation, direction and retinal disparity are all strongly related to the organization for spatial location of light (ON) and dark (OFF) stimuli, an organization that we show is OFF-dominated, OFF-centric and runs orthogonal to ocular dominance columns. Because this ON/OFF organization originates from the clustering of ON and OFF thalamic afferents in visual cortex, we conclude that all main features of cortical topography, including orientation, direction and retinal disparity, follow a common organizing principle that arranges thalamic axons with similar retinotopy and ON/OFF polarity in neighboring cortical regions.