THE TOPOGRAPHY OF CALLOSAL READING PATHWAYS - A CASE-CONTROL ANALYSIS
THE TOPOGRAPHY OF CALLOSAL READING PATHWAYS - A CASE-CONTROL ANALYSIS
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DOI：
10.1093/brain/115.6.1807
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发表时间：
1992-12-01
期刊：
影响因子：
14.5
通讯作者：
MOHR, JP
中科院分区：
文献类型：
--
作者：
BINDER, JR;MOHR, JP
本文分析了17例大脑后动脉优势区梗塞患者的病灶地形图和阅读能力。阅读不受影响的显性大脑后动脉梗死患者作为解剖对照组。正常阅片者枕叶内侧和腹侧有病变，背侧白色物质通路和腹侧颞叶除外。只有在压部、大镊或侧脑室枕角上方的白色物质受到额外损伤时，才会出现全面性和永久性失读症。这些数据表明，介导阅读的胼胝体通路位于枕角上方，与枕腹内侧区几乎没有联系。患有“拼写障碍”的患者的腹侧颞叶有很大的病变，涉及到被认为参与后期视觉处理的皮质区域。这些研究结果提供了一个框架，根据病变的地形预测阅读障碍的类型和严重程度。
Lesion topography and reading ability were analysed in 17 patients with dominant posterior cerebral artery territory infarction. Patients with dominant posterior cerebral artery infarction in whom reading was unaffected served as an anatomical control group. Normal readers had lesions in the medial and ventral occipital lobe, sparing dorsal white matter pathways and the ventral temporal lobe. Global and permanent alexia occurred only with additional injury to the splenium, forceps major or white matter above the occipital horn of the lateral ventricle. These data suggest that callosal pathways mediating reading lie above the occipital horn and have little connection with the ventromedial occipital region. Patients with 'spelling dyslexia' had large lesions of the ventral temporal lobe involving cortical regions believed to participate in later stages of visual processing. These findings provide a framework for the prediction of dyslexia type and severity based on lesion topography.