VASOACTIVE INTESTINAL PEPTIDE AND WATERY-DIARRHŒA SYNDROME
VASOACTIVE INTESTINAL PEPTIDE AND WATERY-DIARRHŒA SYNDROME
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血管活性肠肽与水样腹泻综合征
DOI：
10.1016/s0140-6736(73)91947-8
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
A. Pearse
中科院分区：
文献类型：
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作者：
S. Bloom;J. Polak;A. Pearse
6例watery-diarrhœa综合征（胰型霍乱）患者经特异性放射免疫测定发现血浆血管活性肠肽（V.I.P.）水平升高和/或肿瘤含量高。在两例可获得适当固定肿瘤材料的病例中，获得了V.I.P.抗血清的免疫荧光阳性。V.I.P.的已知行为与watery-diarrhœa综合征中发现的异常非常吻合。等离子vip的可用性。化验可以在肿瘤转移发生前作出诊断。
Six patients with the watery-diarrhœa syndrome (pancreatic cholera) were found to have raised plasma levels and/or high tumour content of vasoactive intestinal peptide (V.I.P.), as measured by a specific radioimmunoassay. Positive immunofluorescence with V.I.P. antisera was obtained in two cases in which properly fixed tumour material was available. The known actions of V.I.P. accord well with the abnormalities found in the watery-diarrhœa syndrome. The availability of a plasma-V.I.P. assay may enable the diagnosis to be made before tumour metastasis occurs.