A powerful tool to study metabolic reprogramming in pediatric cancers.

A powerful tool to study metabolic reprogramming in pediatric cancers.
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DOI：
10.1016/j.medj.2021.03.006
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发表时间：
2021-04
期刊：
Med
影响因子：
17
通讯作者：
R. Missiaen;M. Simon
R. Missiaen;M. Simon
中科院分区：
--
文献类型：
--
作者：
R. Missiaen;M. Simon

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约翰斯顿等人。开发了一种术中 U13C-葡萄糖输注方案，该方案对于儿科癌症患者具有良好的耐受性，并显示出具有治疗效果的癌症类型特异性代谢变化。该程序的开发及其研究结果将极大有利于儿科癌症的代谢分析和新治疗策略的设计。
Johnston et al. developed an intra-operative U13C-glucose infusion protocol that is well tolerated by patients with pediatric cancers and shows cancer-type-specific metabolic alterations with therapeutical consequences. The development of this procedure and their findings will strongly benefit metabolic analysis of pediatric cancers and design of new therapeutic strategies.