A macrophage activation marker chitotriosidase in women with PCOS: does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity?
A macrophage activation marker chitotriosidase in women with PCOS: does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity?
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DOI：
10.1007/s00404-012-2425-0
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发表时间：
2012-10-01
影响因子：
2.6
通讯作者：
Tapan, Serkan
中科院分区：
文献类型：
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作者：
Alanbay, Ibrahim;Ercan, Cihangir Mutlu;Tapan, Serkan
多囊卵巢综合征(PCOS)被描述为一种低度慢性炎症状态，其中巨噬细胞在内脏脂肪浸润增加中起主要作用。本研究的目的是评价多囊卵巢综合征(PCOS)患者和对照组中几丁三糖苷酶(CHT)活性(一种激活的巨噬细胞标志物)的活性，并评价其与人体测量学和生化参数的相关性。根据体重指数(BMI)将PCOS和对照组分为正常体重(25 kg/m(2))和超重(25 kg/m(2))两个亚组。CHT活性、生化指标(游离睾酮、黄体生成素、胰岛素抵抗指数等)多囊卵巢综合征患者血清CHT活性显著高于正常体重对照组(87.1+/-A90.1比18.4+/-A9.0nmol/ml/h；超重，92.0+/-A96.7比17.9+/-A12.1nmol/ml/h，P<；0.001)。PCOS正常体重亚组和超重PCOS亚组CHT活性差异无统计学意义。在PCOS+对照组中，CHT活动与PCOS状态(r 0.598，p&t；0.001)、MFG评分(r 0.525，p&t；0.001)、游离睾酮(r 0.402，p 0.001)和总睾酮(r 0.168，p 0.048)呈正相关。在多元线性回归分析中，参与者的多囊卵巢综合征状态(有无)和促黄体生成素水平是整个研究人群中CHT活动的主要预测因素(分别为p 0.002和p 0.041)。我们的发现支持PCOS是一种低度慢性炎症状态的概念，其中巨噬细胞可能起主要作用。高雄激素血症也可能与这种炎症状态有关，并可能成为进一步试验的主题。
Polycystic ovary syndrome (PCOS) is described as a low-grade chronic inflammatory state where the macrophage infiltration increased in visceral fat play the major role. The aim of this study was to assess chitotriosidase (ChT) activity (an activated macrophage marker) in women with PCOS and controls and to evaluate its correlation with anthropometric and biochemical parameters.Seventy-nine women with PCOS and 60 healthy controls were included in the study. PCOS and controls were divided into two subgroups according to body mass indexes (BMIs) as normoweight (< 25 kg/m(2)) and overweight (a parts per thousand yen25 kg/m(2)). ChT activity, biochemical (free testosterone, luteinizing hormone, insulin resistance index, etc.) and clinical parameters [BMI, waist-to-hip ratio, modified Ferriman-Gallwey scores (mFG)] were analyzed according to groups.Serum ChT activity was significantly (p < 0.001) higher in women with PCOS than controls (normoweight, 87.1 +/- A 90.1 vs. 18.4 +/- A 9.0 nmol/ml/h; overweight, 92.0 +/- A 96.7 vs. 17.9 +/- A 12.1 nmol/ml/h PCOS and controls, respectively). No statistically significant difference was noted between ChT activity of normoweight and overweight PCOS subgroups. A positive correlation was found between ChT activity and PCOS status (r 0.598, p < 0.001), mFG scores (r 0.525, p < 0.001), free testosterone (r 0.402, p 0.001) and total testosterone (r 0.168, p 0.048) for the combined groups (PCOS + controls). In multivariant linear regression analysis participants' PCOS status (presence or absence) and LH levels were the main predictors of ChT activity in the whole study population (p 0.002 and p 0.041, respectively).ChT activity elevates in PCOS independent of obesity. Our findings support the concept of PCOS is a state of low-grade chronic inflammation where the macrophages could play the major role. Hyperandrogenism might also be related to this inflammatory state and can be a subject of further trials.