Temperature and Term Low Birth Weight in California
Temperature and Term Low Birth Weight in California
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DOI：
10.1093/aje/kwy116
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发表时间：
2018-11-01
影响因子：
5
通讯作者：
Malig, Brian
中科院分区：
文献类型：
--
作者：
Basu, Rupa;Rau, Reina;Malig, Brian
很少有研究探讨温度和分娩结果。在一项回顾性队列研究中，我们检查了加州（1999-2013年）43，629名足月低出生体重儿和2，032，601名正常体重儿的表观温度（温度和相对湿度的组合）和足月低出生体重儿（LBW）。加州公共卫生部提供了出生证明数据，而气象数据则来自加州灌溉管理信息系统、美国环境保护署和国家环境信息中心。在考虑了几个温度指标后，我们观察到最适合整个妊娠期LBW的模型（表观温度每增加10华氏度，13.0%变化，95%置信区间：4.1，22.7），最大的关联是在60华氏度以上的第三个三个月的暴露（15.8%，95%置信区间：5.0，27.6）。怀孕第一个月的表观温度没有显着的风险，而前三个月有显着的负相关，第二个三个月，最后一个月和最后两周的风险略有增加。黑人或年龄较大的母亲，产下男婴或在温暖季节分娩的婴儿风险最高。这项研究提供了进一步的证据表明，热暴露对孕妇的脆弱亚组的不良出生结果。
Few investigations have explored temperature and birth outcomes. In a retrospective cohort study, we examined apparent temperature, a combination of temperature and relative humidity, and term low birth weight (LBW) among 43,629 full-term LBW infants and 2,032,601 normal-weight infants in California (1999-2013). The California Department of Public Health provided birth certificate data, while meteorological data came from the California Irrigation Management Information System, US Environmental Protection Agency, and National Centers for Environmental Information. After considering several temperature metrics, we observed the best model fit for term LBW over the full gestation (per 10-degrees-Fahrenheit (degrees F) increase in apparent temperature, 13.0% change, 95% confidence interval: 4.1, 22.7) above 55 degrees F, and the greatest association was for third-trimester exposure above 60 degrees F (15.8%, 95% confidence interval: 5.0, 27.6). Apparent temperature during the first month of pregnancy exhibited no significant risk, while the first trimester had a significantly negative association, and second trimester, last month, and last 2 weeks had slightly increased risks. Mothers who were black or older, delivered male infants, or gave birth during the warm season had infants at the highest risks. This study provides further evidence for adverse birth outcomes from heat exposure for vulnerable subgroups of pregnant women.