Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis.
Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis.
复制标题
在鉴定循环蛋白质中的质谱质谱法的应用不能预测早期精神病的未来体重增加。
DOI：
10.1186/s12014-020-09299-2
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发表时间：
2020
影响因子：
3.8
通讯作者：
Deakin B
中科院分区：
文献类型：
--
作者：
Heald A;Azadbakht N;Geary B;Conen S;Fachim H;Lee DCH;Geifman N;Farman S;Howes O;Whetton A;Deakin B
体重增加是抗精神病药物治疗早期精神病的常见结果，导致进一步的发病率和治疗依从性差。确定可以预测早期精神病体重变化的工具可能有助于更好地个性化治疗和依从性。最近，我们表明，蛋白质组学分析与连续窗口采集的所有理论碎片离子光谱（SWATH）质谱（MS）可以识别个体糖尿病前期更有可能经历体重变化与生活方式的改变。我们研究了基线蛋白质组学谱是否预测了体重随时间的变化，使用的数据来自BeneMin的抗炎抗生素米诺环素与安慰剂的临床试验。通过SWATH蛋白质组学在83人（60名男性和23名女性）中测定了844种蛋白质的表达水平。基线蛋白质组学数据的层次聚类分析和主成分分析没有显示出不同体重变化类别参与者的蛋白质组谱之间的明显分离。然而，体重减轻最多的个体具有较高的阳性和阴性症状量表（PANSS）评分。我们的研究结果意味着治疗模式，即精神病的药物干预可能是诊断后体重变化的决定因素，而不是诱发蛋白质组学动力学。
Weight gain is a common consequence of treatment with antipsychotic drugs in early psychosis, leading to further morbidity and poor treatment adherence. Identifying tools that can predict weight change in early psychosis may contribute to better-individualised treatment and adherence. Recently we showed that proteomic profiling with sequential window acquisition of all theoretical fragment ion spectra (SWATH) mass spectrometry (MS) can identify individuals with pre-diabetes more likely to experience weight change in relation to lifestyle change. We investigated whether baseline proteomic profiles predicted weight change over time using data from the BeneMin clinical trial of the anti-inflammatory antibiotic, minocycline, versus placebo. Expression levels for 844 proteins were determined by SWATH proteomics in 83 people (60 men and 23 women). Hierarchical clustering analysis and principal component analysis of baseline proteomics data did not reveal distinct separation between the proteome profiles of participants in different weight change categories. However, individuals with the highest weight loss had higher Positive and Negative Syndrome Scale (PANSS) scores. Our findings imply that mode of treatment i.e. the pharmacological intervention for psychosis may be the determining factor in weight change after diagnosis, rather than predisposing proteomic dynamics.
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
CATIE精神分裂症试验体重变化与症状减轻之间的关联。
影响因子：
4.5
作者：
Hermes, Eric;Nasrallah, Henry;Davis, Vicki;Meyer, Jonathan;McEvoy, Joseph;Goff, Donald;Davis, Sonia;Stroup, T. Scott;Swartz, Marvin;Lieberman, Jeffrey;Rosenheck, Robert
通讯作者：
Rosenheck, Robert
影响因子：
4.3
作者：
Hill SK;Bishop JR;Palumbo D;Sweeney JA
通讯作者：
Sweeney JA
影响因子：
3.4
作者：
HALL, RCW
通讯作者：
HALL, RCW
影响因子：
10.5
作者：
ADDINGTON, D;ADDINGTON, J;MATICKATYNDALE, E
通讯作者：
MATICKATYNDALE, E