Sex with older partners is associated with primary HIV infection among men who have sex with men in North Carolina.
Sex with older partners is associated with primary HIV infection among men who have sex with men in North Carolina.
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DOI：
10.1097/qai.0b013e3181c99114
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Hightow-Weidman LB
中科院分区：
文献类型：
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作者：
Hurt CB;Matthews DD;Calabria MS;Green KA;Adimora AA;Golin CE;Hightow-Weidman LB
20世纪90年代的研究表明，与年长伴侣发生性关系与艾滋病毒感染有关。我们评估了男男性行为者（MSM）中原发性HIV感染（PHI）和有年长性伴侣之间的假设关联。患有PHI的MSM和未感染HIV的MSM在登记（如果未感染）或诊断（如果PHI）之前完成了音频计算机辅助自我访谈，探索涉及其最近三个性伴侣的行为。在74名报告与男性发生终生性关系的男性中，20人患有PHI（27%）。两组之间的人口统计学（包括年龄）相似; 39%是非白人，74%被确定为同性恋。性伴侣的平均年龄有显著差异：患有PHI的男性的性伴侣平均比自己大6岁，而未感染的男性的性伴侣比自己小4个月（P<0.001）。在调整种族、醉酒时的性别和有血清不一致/血清状态未知的伴侣后，如果他的性伴侣比他大5岁，参与者发生PHI的几率是他的两倍（OR 2.0，95%CI，1.2，3.3）。在年轻男男性接触者的样本中，随着性伴侣年龄的增加，艾滋病毒感染的几率显著增加。这些发现可以为高危MSM社区的行为干预以及已经感染艾滋病毒的人的二级预防工作提供信息。
Studies from the 1990s suggested sex with older partners was associated with HIV infection. We evaluated the hypothesized association between primary HIV infection (PHI) and having older sexual partners among men who have sex with men (MSM). MSM with PHI and HIV-uninfected MSM completed audio computer-assisted self-interviews exploring behaviors involving their three most recent sexual partners prior to enrollment (if uninfected) or diagnosis (if PHI). Of 74 men reporting any lifetime sex with men, 20 had PHI (27%). Demographics (including age) were similar between groups; 39% were non-white and 74% identified as gay. The mean age of sex partners differed significantly: men with PHI had partners on average 6 years older than themselves, while uninfected men’s partners were 4 months their junior (P<0.001). After adjusting for race, sex while intoxicated, and having a serodiscordant/serostatus unknown partner, a participant had twice the odds of PHI if his sex partner was 5 years his senior (OR 2.0, 95% CI, 1.2, 3.3). Among a sample of young MSM, the odds of HIV infection increased significantly as the age of sexual partners increased. These findings can inform behavioral interventions in communities of at-risk MSM as well as secondary prevention efforts among those already living with HIV.