Deleterious background selection with recombination.
Deleterious background selection with recombination.
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作者：
R. Hudson;N. Kaplan
对于具有有害突变和重组的区域中的中性基因，得到了期望的核苷酸多样性的解析表达式。我们的分析结果被用来预测果蝇整个第三条染色体的变异水平。这些预测与在黑腹金龟子第三条染色体着丝粒附近观察到的低水平变异是一致的。然而，使用目前可用的有害突变率和选择系数的估计，无法预测在该染色体顶端观察到的低水平变异。如果假设选择系数相当小，则在第三条染色体顶端观察到的低水平变异与背景选择模型是一致的。
An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have been observed at loci near the centromeres of the third chromosome of D. melanogaster. However, the low levels of variation observed near the tips of this chromosome are not predicted using currently available estimates of the deleterious mutation rate and of selection coefficients. If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model.