Translational controls impinging on the 5'-untranslated region and initiation factor proteins
Translational controls impinging on the 5'-untranslated region and initiation factor proteins
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DOI：
10.1016/s0959-437x(97)80133-5
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发表时间：
1997-04-01
影响因子：
4
通讯作者：
Wickens, M
中科院分区：
文献类型：
--
作者：
Jackson, RJ;Wickens, M
Translation of eukaryotic mRNAs is generally initiated by the scanning ribosome mechanism. This can be downregulated by high affinity protein binding to cap-proximal RNA motifs. Translation can also be regulated by short open reading frames within the 5'-untranslated region. A key factor for initiation is eIF4F, in which one of the polypeptide chains, eIF4G, seems to have a bridging function and binds three other factors at separate sites: eIF4E (the cap-binding factor), the helicase eIF4A, and eIF3, which also interacts with 40S ribosomal subunits. Initiation is regulated by the MAP kinase and rapamycin-sensitive signalling pathways, which control phosphorylation of eIF4E and 4E-BP1, a protein which in the dephosphorylated form binds and sequesters eIF4E.
