Langerhans cells of the ocular surface.
Langerhans cells of the ocular surface.
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DOI：
10.1016/s0161-6420(82)34737-5
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发表时间：
1982-06
期刊：
影响因子：
13.7
通讯作者：
Thomas E. Gillette;John W. Chandler;Jack V. Greiner
中科院分区：
文献类型：
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作者：
Thomas E. Gillette;John W. Chandler;Jack V. Greiner
最近的证据已经收集了几个研究人员定义了一个独特的群体的树突状细胞（朗格汉斯细胞）的间充质起源居住在许多哺乳动物物种的表皮表面。这些细胞在处理通过皮肤表面呈递的抗原中起主导作用，并携带II类组织相容性抗原，该抗原被认为在同种异体移植排斥的传入臂中具有核心重要性。它们还具有在免疫应答的传出臂中活跃的巨噬细胞的许多特征。在人、小鼠、大鼠和豚鼠的眼表上皮中，树突状细胞（朗格汉斯细胞）的等效亚群已通过酶组织化学、免疫荧光和电子显微镜鉴定。眼表面朗格汉斯细胞在角膜炎症（远程和最近）的情况下增殖，并被局部和全身皮质类固醇耗尽。眼表朗格汉斯细胞可能在眼接触性超敏反应、角膜移植排斥反应和眼表免疫监视中发挥重要作用。
Recent evidence has been collected by several investigators defining a distinct population of dendritic cells (Langerhans cells) of mesenchymal origin residing in the epidermal surfaces of many mammalian species. These cells play a dominant role in the processing of antigens presented through cutaneous surfaces and carry a Class II histocompatability antigen felt to be of central importance in the afferent arm of allograft rejection. They also possess many of the characteristics of macrophages active in the efferent arm of immunologic responses. An equivalent subset of dendritic cells (Langerhans cells) in ocular surface epithelium of the human, mouse, rat, and guinea pig has been identified by enzyme histochemistry, immunofluorescence, and electron microscopy. Ocular surface Langerhans cells proliferate in the setting of corneal inflammation (remote and recent) and are depleted by topical and systemic corticosteroids. Ocular surface Langerhans cells may play a central role in ocular contact hypersensitivity, corneal allograft rejection, and ocular surface immune surveillance.