Circulating soluble form of LR11, a regulator of smooth muscle cell migration, is a novel marker for intima-media thickness of carotid arteries in type 2 diabetes
Circulating soluble form of LR11, a regulator of smooth muscle cell migration, is a novel marker for intima-media thickness of carotid arteries in type 2 diabetes
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循环可溶形式的 LR11 是平滑肌细胞迁移的调节剂，是 2 型糖尿病颈动脉内膜中层厚度的新标志物
DOI：
10.1016/j.cca.2016.04.016
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发表时间：
2016
影响因子：
5
通讯作者：
Hideaki Bujo
中科院分区：
文献类型：
--
作者：
Wenlong Jin;Meizi Jiang;Xinhua Han;Xuehua Han;Takeyoshi Murano;Nobuyuki Hiruta;Hiroyuki Ebinuma;Lianshan Piao;Wolfgang J. Schneider;Hideaki Bujo
背景平滑肌细胞（smooth muscle cell，SMC）从中膜向内膜迁移是晚期动脉粥样硬化斑块稳定性的一个重要过程，受LR 11的调控。为探讨2型糖尿病（T2 D）患者血浆可溶性LR 11（sLR 11）水平的变化及其临床意义，对165例T2 D患者血浆sLR 11水平与颈动脉内膜中层厚度（IMT）进行了相关性分析（平均年龄56.2 ± 10.4岁，58.2%为男性，BMI 24.6 ± 3.6）。结果血清sLR 11水平为9.8 ± 3.5ng/ml，与年龄、性别、收缩压、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、糖化血红蛋白（HbA 1c）呈正相关。多元线性回归分析显示，sLR 11与IMT、年龄、FPG呈正相关，与LDL-C的相关性较小。在IMT的血清危险因素中，多元线性回归分析发现sLR 11与IMT独立相关。随后的逻辑分析显示，FPG相关性最好的IMT值在0.80毫米和sLR 11在0.90毫米的截止值，分别，而LDL-C显示较低的歧视权力在任何IMT截止value.ConclusionIncreased sLR 11浓度与IMT增加，以及与FPG在中年，非肥胖的T2 D患者。循环sLR 11可能是T2 D患者内膜SMC病理生理学的新标志物。
BackgroundSmooth muscle cell (SMC) migration from the media to the intima, a process affecting plaque stability in advanced-stage atherosclerosis, is under the control of LR11. To delineate the clinical significance of the circulating soluble form of LR11 (sLR11) in patients with type 2 diabetes (T2D), we analyzed the correlation of sLR11 levels with intima-media thickness (IMT) of carotid arteries.MethodsPlasma sLR11 levels were measured in 165 patients with T2D (mean age 56.2 ± 10.4 y, 58.2% males, and BMI 24.6 ± 3.6) by ELISA. Averaged IMT levels of common carotid arteries were determined by ultrasonography.ResultsCirculating sLR11 levels were 9.8 ± 3.5 ng/ml, and correlated positively with the classical atherosclerosis risk factors age, sex, systolic blood pressure, low-density lipoprotein-cholesterol (LDL-C), fasting plasma-glucose (FPG), and glycosylated hemoglobin. Multivariate linear regression analysis indicated that only FPG was associated with sLR11; sLR11 correlated positively with IMT, together with age and FPG, but less with LDL-C. Among the serum risk factors for IMT, multivariate linear regression analysis uncovered that sLR11 was independently associated with IMT. Subsequent logistic analysis revealed that FPG correlated best with IMT values at a cut-off of 0.80 mm and sLR11 at a cut-off of 0.90 mm, respectively, while LDL-C showed lower discriminatory power at any IMT cut-off values.ConclusionIncreased sLR11 concentrations are highly associated with increased IMT as well as with FPG in middle-aged, non-obese patients with T2D. Circulating sLR11 may be a novel marker representing the pathophysiology of intimal SMCs in patients with T2D.