Relationship between oxidative stress-related biomarkers and antioxidant status with asthma and atopy in young adults: a population-based study
Relationship between oxidative stress-related biomarkers and antioxidant status with asthma and atopy in young adults: a population-based study
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DOI：
10.1111/j.1365-2222.2008.03163.x
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发表时间：
2009-03-01
影响因子：
6.1
通讯作者：
Rona, R. J.
中科院分区：
文献类型：
--
作者：
Garcia-Larsen, V.;Chinn, S.;Rona, R. J.
据报道，患有哮喘症状和肺功能差的成年人氧化应激增强。这项研究评估了年轻人中氧化应激和抗氧化状态标志物与肺功能、哮喘症状、特应性和支气管高反应性 (BHR) 之间的关系。从评估慢性病早期和当前危险因素的调查中总共 1232 人中选出了 589 名 22-28 岁个体的子样本，参与了这项研究。参与者来自智利的农业区，回答了西班牙版的欧洲共同体呼吸健康调查问卷，对八种过敏原进行了皮肤测试，并用乙酰甲胆碱进行了挑战以评估 BHR。对 585 名受试者进行了血浆生物标志物铁还原能力、尿酸、羰基蛋白的测量，并对 564 名受试者进行了 8-异前列腺素 F-2 α (8-iso-PGF(2 α)) 评估。所有参与者均检测到了血浆 8-iso-PGF(2 α) 和羰基水平。没有迹象表明抗氧化状态或氧化应激标志物与任何研究结果之间存在关联。在没有更严重症状或恶化的情况下，血浆中氧化应激相关生物标志物和抗氧化状态的水平可能与普通人群的哮喘无关。
Enhanced oxidative stress has been described in adults who suffer from symptoms of asthma and poor lung function. This study assessed the relation between markers of oxidative stress and antioxidant status and lung function, symptoms of asthma, atopy and bronchial hyperresponsiveness (BHR) in young adults.A sub-sample of 589 individuals aged 22-28 years, selected from a total of 1232 included in a survey assessing early and current risk factors for chronic diseases, participated in the study. Participants were from an agricultural area of Chile, responded to a Spanish version of the European Community Respiratory Health Survey questionnaire, were skin tested to eight allergens, and challenged with methacholine to assess BHR. Five hundred and eighty-five individuals had measures of plasma biomarkers ferric reducing ability of plasma, uric acid, protein carbonyls and 564 had 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha)) assessed.All participants had detectable plasma 8-iso-PGF(2 alpha) and carbonyl levels. There was no indication for an association between markers of antioxidant status or oxidative stress with any of the outcomes studied.The levels of oxidative stress-related biomarkers and antioxidant status in plasma may not be related to asthma in the general population in the absence of more severe symptoms or exacerbations.