Dynamic regulatory interactions of Polycomb group genes:: MEDEA autoregulation is required for imprinted gene expression in Arabidopsis
Dynamic regulatory interactions of Polycomb group genes:: MEDEA autoregulation is required for imprinted gene expression in Arabidopsis
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DOI：
10.1101/gad.378106
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发表时间：
2006-05-01
影响因子：
10.5
通讯作者：
Grossniklaus, U
中科院分区：
文献类型：
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作者：
Baroux, U;Gagliardini, V;Grossniklaus, U
拟南芥Polycomb group （PcG）基因MEDEA （MEA）与Zeste增强子[E(Z)]同源，是种子正常发育的母系必需基因。本研究表明，与已知的哺乳动物印迹基因不同，MEA调节其自身的印迹表达：它在受精前后下调母体等位基因，并在种子发育后期保持父本等位基因沉默。母体MEA等位基因的自抑制与动物的E(Z)-ESC （Extra sex comb）复合体类似，直接独立于MEA- fie（受精独立胚乳）PcG复合体，提示了一种新的机制。MEA-FIE PcG复合体的其他已知成员之间的交叉调节相互作用的复杂网络意味着在繁殖过程中动态调节的不同功能。
The imprinted Arabidopsis Polycomb group (PcG) gene MEDEA (MEA), which is homologous to Enhancer of Zeste [E(Z)], is maternally required for normal seed development. Here we show that, unlike known mammalian imprinted genes, MEA regulates its own imprinted expression: It down-regulates the maternal allele around fertilization and maintains the paternal allele silent later during seed development. Autorepression of the maternal MEA allele is direct and independent of the MEA-FIE (FERTILIZATION-INDEPENDENT ENDOSPERM) PcG complex, which is similar to the E(Z)-ESC (Extra sex combs) complex of animals, suggesting a novel mechanism. A complex network of cross-regulatory interactions among the other known members of the MEA-FIE PcG complex implies distinct functions that are dynamically regulated during reproduction.