NEW ANTIBIOTICS FROM STRAINS OF TRICHODERMA-HARZIANUM
NEW ANTIBIOTICS FROM STRAINS OF TRICHODERMA-HARZIANUM
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DOI：
10.1021/np50074a008
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发表时间：
1991-03-01
影响因子：
5.1
通讯作者：
SIVASITHAMPARAM, K
中科院分区：
文献类型：
--
作者：
ALMASSI, F;GHISALBERTI, EL;SIVASITHAMPARAM, K
对从小麦根部分离的两株哈茨木霉在液体培养中产生的代谢产物进行了检测。71号菌株产生三种化合物，对全食真菌--禾谷盖曼氏变种具有抗菌活性。小黑麦。化合物1和2以前已经从康氏木霉和哈茨木霉中分离出来。第三个也是主要的代谢物3是一种八肽衍生的缩醛二醇，通过对3及其衍生物的详细光谱分析，推导出了它的结构。73菌株阐述了两种新的丁烯内酯代谢产物，其中含有3，4-二烷基呋喃-2(5H)-一核。这两种代谢物都能拮抗全食真菌的生长。
The metabolites produced in liquid cultures by two strains of Trichoderma harzianum, isolated from wheat roots, have been examined. Strain 71 produces three compounds with antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici. Compounds 1 and 2 have been isolated previously from strains of Trichoderma koningii and T. harzianum. The structure of the third and major metabolite 3, an octaketide-derived acetal diol, has been deduced from detailed spectroscopic analysis of 3 and its derivatives. Strain 73 elaborates two new butenolide metabolites containing the 3,4-dialkylfuran-2(5H)-one nucleus. Both metabolites antagonize the growth of the take-all fungus.