Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects.
Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects.
复制标题
新生儿时期的条件性呼吸抑制与乙醇气味和药物的中毒作用有关。
DOI：
10.1002/dev.21398
复制
发表时间：
2016
影响因子：
2.2
通讯作者：
Molina,JC
中科院分区：
文献类型：
--
作者：
Macchione,AF;Anunziata,F;Culleré,ME;Haymal,BO;Spear,N;Abate,P;Molina,JC
已在不同哺乳动物中描述了胎儿和新生儿呼吸系统的乙醇相关改变。研究还表明，perinates了解乙醇的感官属性，并将其与醉酒状态的各种生理效应联系起来。本研究在相当于人类妊娠晚期的发育阶段的新生大鼠中进行。主要目的是分析乙醇气味暴露的后果，中毒状态，或这些因素之间的时间连续性对呼吸模式的影响。主要发现如下：（a）在少数试验（通过乙醇气味和中毒状态之间的关联定义）后观察到条件性呼吸抑制，（B）连续暴露于乙醇使生物体对药物的呼吸抑制作用敏感，而不影响乙醇代谢。这些结果表明，乙醇引起的早期呼吸中断可以通过学习过程来确定或调节。© 2016 Wiley Periodicals，Inc. Dev Psychobiol 58：670-686，2016.
Fetal and neonatal ethanol‐related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The present study was conducted in rat neonates during a developmental stage equivalent to the third human gestational trimester. The major goal was to analyze the consequences of ethanol odor exposure, the state of intoxication, or the temporal contiguity between these factors upon breathing patterns. The main findings were as follows: (a) a conditioned breathing depression was observed following few trials defined by the association between ethanol odor and the state of intoxication and (b) sequential exposure to ethanol sensitizes the organism to the drug's respiratory depressant effects without affecting ethanol metabolism. These results indicate that early breathing disruptions caused by ethanol can be determined or modulated via learning processes. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:670–686, 2016.