A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome.
A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome.
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血小板减少综合征患者转录组和表观遗传谱的纵向抽样研究
DOI：
10.1038/s41467-021-25804-z
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发表时间：
2021-09-24
影响因子：
16.6
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Wang Y;Han S;Ran R;Li A;Liu H;Liu M;Duan Y;Zhang X;Zhao Z;Song S;Weng X;Liu SM;Zhou X
严重发热伴血小板减少综合征（SFTS）是由新型SFTS病毒（SFTSV）引起的一种新型蜱媒传染病。在这里，进行纵向抽样研究，以探讨SFTSV感染后的转录水平的差异，并表征住院患者的转录组学和表观遗传学概况。结果显示，从发病到恢复，某些基因的mRNA表达发生了显着变化。m6 A-seq研究表明，某些与免疫调节相关的基因可能受到m6 A的调控。除血小板计数、血清ALT和AST水平检测等常规检测外，心肌酶、凝血功能和炎症的明显变化与临床数据和测序数据有很好的相关性，提示临床医生应监测上述指标，以跟踪疾病进展并指导个性化治疗。在这项研究中，转录本的变化和RNA修饰可能会为我们提供一个新的视角来了解SFTSV，并在发现有效治疗这种疾病的药物中发挥重要作用。
Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease caused by a new type of SFTS virus (SFTSV). Here, a longitudinal sampling study is conducted to explore the differences in transcript levels after SFTSV infection, and to characterize the transcriptomic and epigenetic profiles of hospitalized patients. The results reveal significant changes in the mRNA expression of certain genes from onset to recovery. Moreover, m6A-seq reveals that certain genes related with immune regulation may be regulated by m6A. Besides the routine tests such as platelet counts, serum ALT and AST levels testing, distinct changes in myocardial enzymes, coagulation function, and inflammation are well correlated with the clinical data and sequencing data, suggesting that clinical practitioners should monitor the above indicators to track disease progression and guide personalized treatment. In this study, the transcript changes and RNA modification may lend a fresh perspective to our understanding of the SFTSV and play a significant role in the discovery of drugs for effective treatment of this disease.
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影响因子：
30.3
作者：
Kennedy EM;Bogerd HP;Kornepati AV;Kang D;Ghoshal D;Marshall JB;Poling BC;Tsai K;Gokhale NS;Horner SM;Cullen BR
通讯作者：
Cullen BR
DOI：
10.1515/1544-6115.1826
发表时间：
2012-01-01
影响因子：
0.9
作者：
Lund, Steven P.;Nettleton, Dan;Smyth, Gordon K.
通讯作者：
Smyth, Gordon K.
影响因子：
20.3
作者：
Donada, Alessandro;Balayn, Nathalie;Raslova, Hana
通讯作者：
Raslova, Hana
影响因子：
50.3
作者：
Li Z;Weng H;Su R;Weng X;Zuo Z;Li C;Huang H;Nachtergaele S;Dong L;Hu C;Qin X;Tang L;Wang Y;Hong GM;Huang H;Wang X;Chen P;Gurbuxani S;Arnovitz S;Li Y;Li S;Strong J;Neilly MB;Larson RA;Jiang X;Zhang P;Jin J;He C;Chen J
通讯作者：
Chen J
流行地区血小板减少综合征发热与肾综合征出血热的鉴别特征
影响因子：
4.2
作者：
Lu, Qing-Bin;Li, Hao;Liu, Wei
通讯作者：
Liu, Wei