Retinal ganglion cell-inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly
Retinal ganglion cell-inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly
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DOI：
10.1016/j.dadm.2018.10.006
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发表时间：
2019-12-01
影响因子：
5.3
通讯作者：
Chen, Yen-Ching
中科院分区：
文献类型：
--
作者：
Liu, Yao-Lin;Hsieh, Yi-Ting;Chen, Yen-Ching
简介：在阿尔茨海默病患者中发现光学相干断层扫描测量的视网膜神经纤维层厚度和神经节细胞内丛状层 (GC-IPL) 厚度变薄。然而，这些视网膜标志物与非痴呆老年人的认知之间的关联可能不是线性的。方法：这项横断面研究包括 227 名社区居住的老年人（年龄 65 岁以上）。进行多变量回归分析以研究视网膜神经纤维层/GC-IPL与全局/特定领域认知之间的关联。结果：随着双侧眼的平均GC-IPL偏离样本平均值（77.5μm），全局认知的表现下降（二次GC-IPL：β = -0.49 x 10-2；95％置信区间：-0.74 x 10（-2）至-0.23×10(-2))。逻辑记忆也发现了类似的关联。未观察到视网膜神经纤维层与认知之间存在显着关联。讨论：GC-IPL 变薄或变厚与非痴呆老年人的认知能力差相关（U 形关联）。 GC-IPL 可作为阿尔茨海默病的无创临床前预测因子。 (C) 2018 作者。由爱思唯尔公司代表阿尔茨海默病协会出版。
Introduction: Thinning of optical coherence tomography-measured retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear.Methods: This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition.Results: The performance of global cognition decreased as mean GC-IPL of bilateral eyes deviated from the sample mean (77.5 mu m) (quadratic GC-IPL: beta = -0.49 x 10-2; 95% confidence interval: -0.74 x 10(-2) to -0.23 x 10(-2)). Similar associations were also found for logical memory. No significant association was observed between retinal nerve fiber layer and cognition.Discussion: Either thinning or thickening of GC-IPL was associated with poor cognition in nondemented elderly (a U-shaped association). GC-IPL may serve as a noninvasive preclinical predictor of Alzheimer's disease. (C) 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.