Formation of nitric oxide from nitrous acid in ischemic tissue and skin
Formation of nitric oxide from nitrous acid in ischemic tissue and skin
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DOI：
10.1016/j.niox.2004.01.004
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发表时间：
2004-02-01
影响因子：
3.9
通讯作者：
Ridd, JH
中科院分区：
文献类型：
--
作者：
Butler, AR;Ridd, JH
一氧化氮（NO）可以在低pH值条件下由亚硝酸形成，而气体N（2）O（3）的形成是速率决定步骤。已发表的数据使我们能够计算出在封闭系统（如循环血浆）中从亚硝酸盐形成NO的速率。由于所涉及的双分子反应，以及亚硝酸盐的浓度非常低，NO的形成速率非常慢。当亚硝酸盐溶液的pH值降低时，NO的浓度可能需要至少12天才能达到足以激活鸟苷酸环化酶的水平，因此自然循环的亚硝酸盐似乎不太可能通过转化为NO参与缺血组织的血管舒张。更现实的是，认为NO是由皮肤上汗液中的亚硝酸盐以生物学显著浓度产生的。(C)2004年爱思唯尔公司All rights reserved.
Nitric oxide (NO) can form from nitrous acid under conditions of low pH and formation of the gas N(2)O(3) is the rate-determining step. Published data allow us to calculate the rate at which NO forms from nitrite in a closed system such as circulating blood plasma. Because of the bimolecular reactions involved, and the very low concentration of nitrite, the rate of formation of NO is very slow. It might take at least 12 days, when the pH of nitrite solution is lowered, for the concentration of NO to reach a level sufficiently high to activate guanylyl cyclase and so it seems unlikely that naturally circulating nitrite is involved in vasodilation in ischemic tissue through its conversion into NO. It is more realistic to consider that NO is produced at biologically significant concentrations from nitrite in perspiration on the skin. (C) 2004 Elsevier Inc. All rights reserved.