Patterns of Polymorphism at the Self-Incompatibility Locus in 1,083 Arabidopsis thaliana Genomes.
Patterns of Polymorphism at the Self-Incompatibility Locus in 1,083 Arabidopsis thaliana Genomes.
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DOI：
10.1093/molbev/msx122
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发表时间：
2017-08-01
影响因子：
10.7
通讯作者：
Castric V
中科院分区：
文献类型：
--
作者：
Tsuchimatsu T;Goubet PM;Gallina S;Holl AC;Fobis-Loisy I;Bergès H;Marande W;Prat E;Meng D;Long Q;Platzer A;Nordborg M;Vekemans X;Castric V
尽管模式植物拟南芥中自交的转变涉及自交不亲和（SI）系统的丧失，但由于在决定SI特异性的基因座（S-基因座）处的单个失活突变的固定，它显然没有发生。至少有三组不同的单倍型（单倍群），对应于古老的功能S-等位基因，一直保持在这个位点，广泛的功能研究表明，所有三个携带不同的失活突变。然而，SI丧失的历史过程并不清楚，特别是它与末次冰期的关系。在这里，我们利用最近发表的基因组重测序数据在1,083拟南芥加入，我们结合BAC测序，以获得整个S-位点区域的多态性信息在物种范围内。加入不同的几个主要的重排，包括大的缺失和单倍群间重组，形成了一套单倍群，广泛分布在整个原生范围，在地理上很大程度上重叠。“遗迹”A直接来自冰川避难所的thaliana加入是多态性的S-位点，这表明，三个单倍型群已经存在时，冰川避难所从最后一个冰河时代成为孤立的。单倍群间重组单倍型非常频繁，重组断点的详细分析表明有多个独立的起源。这些结果表明，完全丧失SI的A。thaliana涉及独立的自交亲和突变体，这些突变体出现在最后一个冰河时代之前，并在冰后期殖民期间经历了进一步的重排。
Although the transition to selfing in the model plant Arabidopsis thaliana involved the loss of the self-incompatibility (SI) system, it clearly did not occur due to the fixation of a single inactivating mutation at the locus determining the specificities of SI (the S-locus). At least three groups of divergent haplotypes (haplogroups), corresponding to ancient functional S-alleles, have been maintained at this locus, and extensive functional studies have shown that all three carry distinct inactivating mutations. However, the historical process of loss of SI is not well understood, in particular its relation with the last glaciation. Here, we took advantage of recently published genomic resequencing data in 1,083 Arabidopsis thaliana accessions that we combined with BAC sequencing to obtain polymorphism information for the whole S-locus region at a species-wide scale. The accessions differed by several major rearrangements including large deletions and interhaplogroup recombinations, forming a set of haplogroups that are widely distributed throughout the native range and largely overlap geographically. “Relict” A. thaliana accessions that directly derive from glacial refugia are polymorphic at the S-locus, suggesting that the three haplogroups were already present when glacial refugia from the last Ice Age became isolated. Interhaplogroup recombinant haplotypes were highly frequent, and detailed analysis of recombination breakpoints suggested multiple independent origins. These findings suggest that the complete loss of SI in A. thaliana involved independent self-compatible mutants that arose prior to the last Ice Age, and experienced further rearrangements during postglacial colonization.
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影响因子：
3.3
作者：
Gervais, Camille E.;Castric, Vincent;Billiard, Sylvain
通讯作者：
Billiard, Sylvain
独立的S-locus突变导致拟南芥的自我育属性。
影响因子：
4.5
作者：
Boggs NA;Nasrallah JB;Nasrallah ME
通讯作者：
Nasrallah ME
影响因子：
64.8
作者：
Gan X;Stegle O;Behr J;Steffen JG;Drewe P;Hildebrand KL;Lyngsoe R;Schultheiss SJ;Osborne EJ;Sreedharan VT;Kahles A;Bohnert R;Jean G;Derwent P;Kersey P;Belfield EJ;Harberd NP;Kemen E;Toomajian C;Kover PX;Clark RM;Rätsch G;Mott R
通讯作者：
Mott R
影响因子：
7.4
作者：
Guo, Ya-Long;Zhao, Xuan;Weigel, Detlef
通讯作者：
Weigel, Detlef
影响因子：
3.3
作者：
Dwyer, Kathleen G.;Berger, Martin T.;Nasrallah, Mikhail E.
通讯作者：
Nasrallah, Mikhail E.