Physiology of Vitreous Substitutes
Physiology of Vitreous Substitutes
复制标题
玻璃体替代物的生理学
DOI：
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
D. Wong
中科院分区：
文献类型：
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作者：
I. Wong;N. Cheung;D. Wong
人玻璃体是一种天然的眼内聚合水凝胶，具有独特的生理生化功能。手术切除玻璃体或玻璃体切除术，现在通常用于治疗许多玻璃体视网膜疾病。这导致需要开发可用于替代玻璃体的物质。尽管玻璃体移植的早期尝试收效甚微，但一系列其他的玻璃体替代品已经被开发出来。理想的替代品应具有玻璃体的所有优良品质，包括透明度、弹性、缓冲能力以及与周围眼组织的生物相容性。然而，目前没有一种玻璃体替代品具有所有这些品质。在现代玻璃体视网膜手术中，短效玻璃体替代物（如空气、平衡盐溶液、膨胀气体）和长效玻璃体替代物（如硅油）都被使用。所有这些替代品都有明显的缺点，主要与缺乏局部生物相容性和生理作用不足有关。在本章中，我们讨论了现有的玻璃体替代品的生物物理、生化和生理特性，以及它们的临床应用、优点和局限性。另一章讨论了人工玻璃体的未来潜力（参见第f章玻璃体生物化学和人工玻璃体）。
Human vitreous is a natural intraocular polymeric hydrogel with distinct biochemical and physiological functions. Surgical removal of the vitreous, or vitrectomy, is now commonly performed for the treatment of many vitreoretinal diseases. This has led to the need for developing substances that can be used to replace vitreous. Although early attempts for vitreous transplantation have yielded little success [1], a range of other vitreous substitutes has been developed. An ideal substitute should have all the good qualities of the human vitreous, including transparency, elasticity, buffer capacity, and biocompatibility with surrounding ocular tissues. However, none of the currently available vitreous substitutes possesses all these qualities. In modern vitreoretinal surgery, both short-acting (e.g., air, balanced salt solutions, expansile gases) and long-acting vitreous substitutes (e.g., silicone oil) are used. All these substitutes have significant shortcomings, mostly related to the lack of local biocompatibility and inadequate physiological role. In this chapter, we discuss the biophysical, biochemical, and physiological properties of the available vitreous substitutes, as well as their clinical use, advantages, and limitations. A separate chapter addresses the future potential of an artificial vitreous [see chapter I.F. Vitreous biochemistry and artificial vitreous].
标准化、多中心眼科手术试验的方法、统计特征和基线结果：硅胶研究。
DOI：
10.1016/0197-2456(91)90022-e
发表时间：
1991
期刊：
Controlled clinical trials
影响因子：
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作者：
Azen,SP;Boone,DC;Barlow,W;McCuen,BW;Walonker,AF;Anderson,MM;Lean,JS;Mowery,RL;Ryan,SJ;Stern,W
通讯作者：
Stern,W
影响因子：
4.2
作者：
通讯作者：
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