Genetic testing for breast and ovarian cancer predisposition: Cancer burden and responsibility
Genetic testing for breast and ovarian cancer predisposition: Cancer burden and responsibility
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DOI：
10.1177/1359105302007004627
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发表时间：
2002-07-01
影响因子：
3.2
通讯作者：
Eeles, R
中科院分区：
文献类型：
--
作者：
Foster, C;Watson, M;Eeles, R
本研究的目的是探讨家庭中的癌症经历和由于家族史而导致乳腺癌和/或卵巢癌风险增加的妇女进行预测性基因检测的动机。15名妇女在接受基因检测结果之前接受了采访。采用扎根理论方法分析访谈记录。研究结果表明，家庭中的癌症经历在制定关于自身风险的信念和预测性基因检测的动机方面发挥着重要作用。对自身健康的责任感和采取行动预防癌症或尽早发现癌症的必要性以及对儿童和其他家庭成员的责任感是显而易见的。调查结果提出了一个问题，即这些妇女是否有任何真实的选择，以及是否对家庭动态产生负面影响。
The purpose of this study was to explore experiences of cancer in the family and motivation for predictive genetic testing among women at increased risk of developing breast and/or ovarian cancer due to their family history. Fifteen women were interviewed prior to receiving their genetic test results. A grounded theory approach was adopted to analyse the interview transcripts. The findings indicated that experiences of cancer in the family play an important role in formulating beliefs about one's own risk and motivation for predictive genetic testing. A sense of responsibility for one's own health and the need to take action either to prevent cancer or detect cancer at as early a stage as possible, as well as a feeling of responsibility towards children and other family members was apparent. The findings raise the question of whether there is any real choice available to these women and whether there is a negative impact on family dynamics.