Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females.
Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females.
复制标题
DOI：
10.1007/s13365-015-0373-8
复制
发表时间：
2016-02
影响因子：
3.2
通讯作者：
Ances BM
中科院分区：
文献类型：
--
作者：
Behrman-Lay AM;Paul RH;Heaps-Woodruff J;Baker LM;Usher C;Ances BM
Most studies that have examined neuropsychological impairments associated with human immunodeficiency virus (HIV) have focused on males, yet females represent one of the largest groups of newly infected patients. Further, few studies have examined neuropsychological performance and neuroimaging outcomes among females compared to males in the modern era of highly active anti-retroviral therapy (HAART). The present study investigated neuropsychological performance and brain volumetrics among HIV+ males (n = 93) and females (n = 44) on stable HAART compared to HIV seronegative (HIV−) males (n = 42) and females (n = 49). An effect of HIV, but not gender, was observed for neuropsychological performance and neuroimaging measures. Additionally, no significant differences in neuropsychological performance or brain volumetrics were seen between HIV+ males and females. No significant interaction was observed between HIV and gender on either neuropsychological or neuroimaging indices. Our results suggest that both HIV+ males and females treated with HAART experience similar outcomes in terms of brain integrity.
