Gold(I)-Catalyzed cascade cyclization reaction: Highly regio- and diastereoselective intermolecular addition of water and alcohols to epoxy alkynes
Gold(I)-Catalyzed cascade cyclization reaction: Highly regio- and diastereoselective intermolecular addition of water and alcohols to epoxy alkynes
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DOI：
10.1021/ol0713640
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发表时间：
2007-08-02
期刊：
影响因子：
5.2
通讯作者：
Shi, Min
中科院分区：
文献类型：
--
作者：
Dai, Lun-Zhi;Qi, Ming-Juan;Shi, Min
我们开发了一种新的方法，通过高度区域选择性和非对映选择性的水和醇分子间加成到由金(I)催化的环氧炔基化合物上。这个过程包括多米诺三元开环，6-外环异构化，以及随后的双键序列的分子内或分子间亲核加成。
[GRAPHICS]We have developed a novel access to ketal skeletons through a highly regio- and diastereoselective intermolecular addition of water and alcohols to alkynyl epoxides catalyzed by gold(I). This procedure involves a domino three-membered ring-opening, 6-exo-cycloisomerization, and subsequent intra- or intermolecular nucleophilic addition to a double-bond sequence.