Facile Synthesis of Isoindolinones via Rh(III)-Catalyzed One-Pot Reaction of Benzamides, Ketones, and Hydrazines.
Facile Synthesis of Isoindolinones via Rh(III)-Catalyzed One-Pot Reaction of Benzamides, Ketones, and Hydrazines.
复制标题
DOI：
10.1021/acs.orglett.5b01016
复制
发表时间：
2015-04
期刊：
影响因子：
5.2
通讯作者：
Yan Zhang;Dahai Wang;Sunliang Cui
中科院分区：
文献类型：
--
作者：
Yan Zhang;Dahai Wang;Sunliang Cui
报道了Rh（III）催化的苯甲酰胺、酮和肼的一锅法反应，以方便地获得异吲哚啉酮。在该方法中，各种酮被转化为给体-给体重氮化合物，其在Rh（III）催化下依次与苯甲酰胺进行插入以生成N-取代的季异吲哚啉酮。
A Rh(III)-catalyzed one-pot reaction of benzamides, ketones, and hydrazines for facile access to isoindolinones is reported. In this method, various ketones are transformed into donor-donor diazo compounds, which sequentially engage in insertion with benzamides under Rh(III) catalysis to generate N-substituted quaternary isoindolinones.