Real-time and background-free detection of nanoscale particles
Real-time and background-free detection of nanoscale particles
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DOI：
10.1103/physrevlett.96.013901
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发表时间：
2006-01-13
影响因子：
8.6
通讯作者：
Novotny, L
中科院分区：
文献类型：
--
作者：
Ignatovich, FV;Novotny, L
我们介绍了一种无背景的实时检测方案，能够识别低指数纳米粒子，如水中的单一病毒。该方法基于干涉测量散射光的电磁场振幅。分裂探测器用于产生无背景信号，对小颗粒表现出前所未有的灵敏度。在目前的配置中，该传感器能够检测水中半径低至10 nm的低折射率颗粒或小至5 nm的单个金颗粒。我们证明了在微流控系统中检测这样的小颗粒的时间分辨率为1毫秒，我们讨论了这种新的检测方案的理论限制。
We introduce a background-free real-time detection scheme capable of recognizing low-index nanoparticles such as single viruses in water. The method is based on interferometrically measuring the electromagnetic field amplitude of the scattered light. A split detector is used to generate a background-free signal that renders unprecedented sensitivity for small particles. In its current configuration the sensor is capable of detecting low-index particles in water down to 10 nm in radius or single gold particles as small as 5 nm. We demonstrate the detection of such small particles in a microfluidic system with a time resolution of 1 ms and we discuss the theoretical limits of this novel detection scheme.