A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.
A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.
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DOI：
10.3233/jad-2009-0992
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Lovell MA
中科院分区：
文献类型：
--
作者：
Lovell MA
虽然多项研究表明锌（Zn）和锌转运（ZnT）蛋白的改变在阿尔茨海默病（AD）的发病机制中的作用，但这种必需微量元素在AD进展中的确切作用仍不清楚。以下综述讨论了锌和ZnT蛋白在脑中的正常作用及其改变在AD发病机制中的潜在影响，特别是在淀粉样前体蛋白和淀粉样β肽的产生和聚集的过程中。
Although multiple studies have suggested a role for alterations of zinc (Zn) and zinc transport (ZnT) proteins in the pathogenesis of Alzheimer’s disease (AD), the exact role of this essential trace element in the progression of AD remains unclear. The following review discusses the normal role of Zn and ZnT proteins in brain and the potential effects of their alteration in the pathogenesis of AD particularly in the processing of the amyloid precursor protein and amyloid beta peptide generation and aggregation.