Parietal memory network and default mode network in first-episode drug-naive schizophrenia: Associations with auditory hallucination
Parietal memory network and default mode network in first-episode drug-naive schizophrenia: Associations with auditory hallucination
复制标题
首次用药史精神分裂症中的顶叶记忆网络和默认模式网络：与幻听的关联
DOI：
10.1002/hbm.24923
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发表时间：
2020-06-01
影响因子：
4.8
通讯作者：
Yang, Zhi
中科院分区：
文献类型：
--
作者：
Guo, Qian;Hu, Yang;Yang, Zhi
静息态网络中的非典型自发活动可能在幻听（AH）中起作用，但与AH相关的网络并不明显。鉴于默认模式网络（DMN）在AH中的辩论作用，顶叶记忆网络（PMN）可能更好地回应精神分裂症AH的认知理论，因为PMN在空间上与DMN相邻，与记忆处理或信息整合更相关。为了研究PMN是否比DMN与AH更相关，我们在静息状态fMRI中对59名首次发作的药物初治精神分裂症患者（26名AH+和33名AH-）和60名健康参与者的AH中的这些内在网络进行了表征。我们使用独立成分分析分离PMN、DMN和听觉网络（AN），并比较三组之间的功能连接。我们发现，只有AH+患者的PMN出现连接障碍，AH+和AH-患者均出现AN功能障碍，但两组患者均未出现DMN内的异常连接。中性粒细胞的连接性与患者的记忆表现显着相关。进一步的区域感兴趣的分析证实，PMN的核心区域之间的连接，左后扣带回和左楔前叶，只有AH+组显着降低。在探索性相关分析中，该功能连接性指标与AH症状的严重程度显著相关。结果提示，与DMN相比，PMN与精神分裂症AH症状的相关性更强，为AH症状的干预提供了更精确的潜在脑调节靶点。
Atypical spontaneous activities in resting-state networks may play a role in auditory hallucinations (AHs), but networks relevant to AHs are not apparent. Given the debating role of the default mode network (DMN) in AHs, a parietal memory network (PMN) may better echo cognitive theories of AHs in schizophrenia, because PMN is spatially adjacent to the DMN and more relevant to memory processing or information integration. To examine whether PMN is more relevant to AHs than DMN, we characterized these intrinsic networks in AHs with 59 first-episode, drug-naive schizophrenics (26 AH+ and 33 AH-) and 60 healthy participants in resting-state fMRI. We separated the PMN, DMN, and auditory network (AN) using independent component analysis, and compared their functional connectivity across the three groups. We found that only AH+ patients displayed dysconnectivity in PMN, both AH+ and AH- patients exhibited dysfunctions of AN, but neither patient group showed abnormal connectivity within DMN. The connectivity of PMN significantly correlated with memory performance of the patients. Further region-of-interest analyses confirmed that the connectivity between the core regions of PMN, the left posterior cingulate gyrus and the left precuneus, was significantly lower only in the AH+ group. In exploratory correlation analysis, this functional connectivity metric significantly correlated with the severity of AH symptoms. The results implicate that compared to the DMN, the PMN is more relevant to the AH symptoms in schizophrenia, and further provides a more precise potential brain modulation target for the intervention of AH symptoms.