Dynamics of striate cortical activity in the alert macaque: I. Incidence and stimulus-dependence of gamma-band neuronal oscillations
Dynamics of striate cortical activity in the alert macaque: I. Incidence and stimulus-dependence of gamma-band neuronal oscillations
复制标题
DOI：
10.1093/cercor/10.11.1105
复制
发表时间：
2000-11-01
期刊：
影响因子：
3.7
通讯作者：
Gray, CM
中科院分区：
文献类型：
--
作者：
Friedman-Hill, S;Maldonado, PE;Gray, CM
利用警觉猕猴纹状体皮质的单单位和多单位记录，我们发现神经元放电中的伽马手(20-70赫兹)振荡是V1神经元活动的一个显著特征。这种节律性活动的性质与以前在猫身上观察到的非常相似。伽马频段的活动强烈依赖于视觉刺激，在自发活动期间基本上不存在，在我们的实验条件下，没有时间锁定到用于呈现刺激的计算机显示器的垂直刷新(80赫兹)。在我们的样本中，61%的多单位活动(MUA)和46%的单单位活动(SUA)是显著振荡的，平均频率分别为48+/-9和42+/-13赫兹。当细胞被其最佳刺激激活时，最有可能发生伽玛波段活动，但仍然发生，尽管频率较低且幅度较低，对非最佳刺激做出反应。伽马频段活动的频率也反映了刺激特性，漂移的栅格比静止的栅格引起更高的频率振荡。与猫一样，呈现伽马频段振荡的单个细胞的棘波序列通常显示出重复的爆发放电模式，爆发内放电频率为300-800赫兹。猫和猴子初级视觉皮质中节律性神经元活动的总体相似性表明，这种现象并不是物种特有的。节律活动的刺激依赖性与视觉知觉中的功能作用是一致的。
Using single and multiunit recordings in the striate cortex of alert macaque monkeys, we find that gamma-hand (20-70 Hz) oscillations in neuronal firing are a prominent feature of V1 neuronal activity. The properties of this rhythmic activity are very similar to those previously observed in the cat. Gamma band activity is strongly dependent on visual stimulation, largely absent during spontaneous activity and, under the conditions of our experiment, not time-locked to the vertical refresh of the computer monitor (80 Hz) used to present the stimuli. In our sample, 61% of multiunit activity (MUA) and 46% of single unit activity (SUA) was significantly oscillatory, with mean frequencies of 48 +/- 9 and 42 +/- 13 Hz, respectively. Gamma band activity was most likely to occur when cells were activated by their optimal stimuli, but still occurred, although less often and with lower amplitude, in response to nonoptimal stimuli. The frequency of gamma-band activity also reflected stimulus properties, with drifting gratings evoking higher-frequency oscillations than stationary gratings. As in the cat, the spike trains of single cells showing gamma-band oscillations often displayed a pattern of repetitive burst firing, with intraburst firing rates of 300-800 Hz. The overall similarity of rhythmic neuronal activity in the primary visual cortex of cats and monkeys suggests that the phenomenon is not species-specific. The stimulus-dependence of the rhythmic activity is consistent with a functional role in visual perception.