Histopathology of uveal melanomas treated with charged particle radiation.
Histopathology of uveal melanomas treated with charged particle radiation.
复制标题
带电粒子辐射治疗葡萄膜黑色素瘤的组织病理学。
DOI：
10.1016/s0161-6420(87)33399-8
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发表时间：
1987
期刊：
影响因子：
13.7
通讯作者：
Char,DH
中科院分区：
文献类型：
--
作者：
Crawford,JB;Char,DH
作者用氦离子照射治疗了255例葡萄膜黑色素瘤。23只眼因并发症被摘除，5只眼在尸检中被取出。我们已经对其中27只眼睛进行了评估。新生血管性青光眼(10只眼)、痛性角膜炎(6只眼)、肿瘤持续生长(4只眼)和玻璃体出血(2只眼)是导致眼球摘除的主要并发症。肿瘤的坏死程度与肿瘤的大小、色素沉着和肿瘤的前部范围有关。它与照射间隔或肿瘤缩小量无关。在接受治疗的肿瘤中，有丝分裂现象极其罕见，这表明肿瘤细胞已经失去了循环的能力。
The authors have treated 255 uveal melanomas with helium ion radiation. Twenty-three eyes have been enucleated because of complications and five eyes have been obtained at autopsy. We have evaluated 27 of these eyes. Neovascular glaucoma (10 eyes), painful keratitis (6 eyes), continued tumor growth (4 eyes), and vitreous hemorrhage (2 eyes) were the major complications of treatment that led to enucleation. The degree of tumor necrosis correlated with the size, pigmentation, and anterior extent of the tumor. It did not correlate with the interval from irradiation or with the amount of tumor shrinkage. Mitotic figures were extremely rare in treated tumors, suggesting that the tumor cells have lost their ability to cycle.