High-risk human papillomavirus in nasopharyngeal carcinoma
High-risk human papillomavirus in nasopharyngeal carcinoma
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DOI：
10.1002/hed.21714
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发表时间：
2012-02-01
影响因子：
2.9
通讯作者：
Westra, William H.
中科院分区：
文献类型：
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作者：
Singhi, Aatur D.;Califano, Joseph;Westra, William H.
背景 人乳头瘤病毒 (HPV) 是口咽癌的一个原因，也被认为是鼻咽癌的病原体。结果。 34 例 (76%) 癌症为 EBV 阳性/HPV 阴性，7 例 (16%) 为 EBV 阴性/HPV 阴性，4 例 (9%) 为 EBV 阴性/HPV 阳性。与非白人患者相比，白人患者的癌症中更容易检测到 HPV（16% vs 0%；p=.03）。在 3 名 HPV 阳性癌症患者和现有分期信息中，所有患者均被发现已扩散至口咽部。所有 HPV 阳性癌症均为 p16 阳性，但 HPV 阴性癌症均未呈 p16 阳性（p
Background Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeal carcinomas.Results. Thirty-four (76%) carcinomas were EBV-positive/HPV-negative, 7 (16%) were EBV-negative/HPV-negative, and 4 (9%) were EBV-negative/HPV-positive. HPV was more likely to be detected in carcinomas from white patients than non-white patients (16% vs 0%; p=.03). Of the 3 patients with HPV-positive carcinomas and available staging information, all were found to have extension into the oropharynx. All HPV-positive carcinomas were p16 positive, but none of the HPV-negative carcinomas were p16 positive (p