Cytologic features of endocervical glandular lesions: Comparison of SurePath, ThinPrep, and conventional smear specimen preparations
Cytologic features of endocervical glandular lesions: Comparison of SurePath, ThinPrep, and conventional smear specimen preparations
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DOI：
10.1002/dc.20782
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发表时间：
2008-04-01
影响因子：
1.3
通讯作者：
Wilbur, David C.
中科院分区：
文献类型：
--
作者：
Belsley, Nicole A.;Tambouret, Rosemary H.;Wilbur, David C.
宫颈内瘤变的细胞学特征在传统和ThinPrep方法中已得到很好的描述，但在SurePath方法中还没有。本研究旨在确定SurePath标本的细胞学特征是否相似。对宫颈内原位腺癌或浸润性宫颈内腺癌的常规、ThinPrep和SurePath标本进行了评价，以了解先前描述的宫颈内瘤变的结构和细胞学特征。广义线性模型用于评估有序多项数据的差异。在评价的18个中，显示统计学差异的唯一特征是结构：大细胞群和单细胞在SurePath制剂和常规涂片中更常见。在常规涂片中更常见羽状变。所有组的个体细胞学特征相同。在所有制备物中均以相同的频率观察到有丝分裂和凋亡碎片。液基标本中宫颈内腺性瘤变的结构和细胞学特征与常规涂片相比，仅显示出细微的结构差异。记住这些差异，几乎相同的标准可以用来识别所有三种标本类型的宫颈内腺体病变。
The cytologic features of endocervical neoplasia have been well-described for conventional and ThinPrep, but not for SurePath, methods. This study is designed to ascertain if cytological features are similar in SurePath specimens. Conventional, ThinPrep and SurePath specimens with either endocervical adenocarcinoma in situ or invasive endocervical adenocarcinoma were evaluated,for architectural and cytological features previously described for endocervical neoplasia. A generalized linear model was used to assess the differences of ordinal multinomial data. Of 18 evaluated, the only features showing statistical differences were architectural: large groups of cells and single cells were more frequent in SurePath preparations and conventional smears. Feathering was more frequently noted in conventional smears. Individual cytological features were identical across all groups. Mitoses and apoptotic debris were seen with equal frequency in all preparations. The architectural and cytologic features of endocervical glandular neoplasia in liquid-based specimens show only subtle architectural differences when compared with conventional smears. Keeping these differences in mind, virtually the same criteria can be used to identify endocervical glandular lesions in all three specimen types.