The Swedish CArdioPulmonary BioImage Study: objectives and design.
The Swedish CArdioPulmonary BioImage Study: objectives and design.
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DOI：
10.1111/joim.12384
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发表时间：
2015-12
影响因子：
11.1
通讯作者：
Rosengren A
中科院分区：
文献类型：
--
作者：
Bergström G;Berglund G;Blomberg A;Brandberg J;Engström G;Engvall J;Eriksson M;de Faire U;Flinck A;Hansson MG;Hedblad B;Hjelmgren O;Janson C;Jernberg T;Johnsson Å;Johansson L;Lind L;Löfdahl CG;Melander O;Östgren CJ;Persson A;Persson M;Sandström A;Schmidt C;Söderberg S;Sundström J;Toren K;Waldenström A;Wedel H;Vikgren J;Fagerberg B;Rosengren A
心肺疾病是世界范围内死亡的主要原因，但由于最近危险因素模式的变化，目前建议的诊断和预防战略可能已经过时。瑞典心肺生物影像研究结合了新的成像技术、大规模组学的进展和流行病学分析，广泛地描述了瑞典3万名年龄在50岁到之间的男性和女性的特征。所获得的信息将用于改进心肺疾病的风险预测，并优化研究疾病机制的能力。2012年完成了一项针对1111名个人的全面试点研究，证明了SCAPIS的可行性以及财务和伦理后果。国家多中心研究的招募工作最近已经开始。
Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large‐scale ‘omics’ and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.