Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit).
Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit).
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易损冠状动脉斑块与突发心脏事件的相关性。
DOI：
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发表时间：
2004
影响因子：
4.4
通讯作者：
Jianglin Fan
中科院分区：
文献类型：
--
作者：
M. Shiomi;Takashi Ito;S. Yamada;S. Kawashima;Jianglin Fan
通常认为冠状动脉破裂倾向斑块在突发心脏事件（急性冠状动脉综合征/心源性猝死）的发生中起重要作用。然而，目前尚不清楚哪些因素或刺激需要触发斑块破裂，以及没有闭塞性血栓的冠状动脉斑块是否会引起突发心脏事件。为了解决这些问题，最近，我们开发了一种自发性心肌梗死的家兔模型[Watanabe遗传性高脂血症（WHHL）MI兔]，并发现该模型具有可能与突发心脏事件相关的几种类型的冠状动脉斑块。虽然WHHLMI家兔的许多冠状动脉斑块在组织学上表现为易破裂，但仅在少数死于MI的动物中检测到真正的破裂。此外，在任何WHHLMI家兔中均未检测到闭塞性血栓。这些发现表明，一些额外的刺激在引起破裂倾向斑块和血栓形成的破坏中起决定性作用。由管腔巨噬细胞积聚引起的近闭塞斑块是WHHLMI兔最常见的特征，表明它们是突发心脏事件的原因。如果通过给予额外的触发因子在WHHLMI兔的易破裂斑块中诱导斑块破裂/血栓形成，WHHLMI兔可能成为研究斑块破裂和血栓形成机制的有用模型，并可能为开发新疗法提供新的手段。
It is generally considered that coronary rupture-prone plaques play an important role in the onset of sudden cardiac events (acute coronary syndromes/sudden cardiac death). However, it is not clear which factors or stimuli are required to trigger plaque rupture and whether coronary plaques without occlusive thrombi can cause sudden cardiac events. To address these issues, recently, we developed a rabbit model of spontaneous myocardial infarction [the Watanabe heritable hyperlipidemic (WHHL) MI rabbit] and found that this model possessed several types of coronary plaques that are possibly correlated to sudden cardiac events. Although many of the coronary plaques of the WHHLMI rabbits appeared histologically to be rupture-prone in nature, true rupture was detected only in the few animals that died of MI. In addition, no occlusive thrombus was detected in any WHHLMI rabbit. These findings suggest that some additional stimuli play a definitive role in causing disruption of rupture-prone plaques and thrombosis. Nearly-occluded plaques caused by a luminal macrophage accumulation are the most common feature of WHHLMI rabbits, suggesting that they are responsible for sudden cardiac events. The WHHLMI rabbit could be a useful model for studying the mechanism(s) of plaque rupture and thrombogenesis if plaque rupture/thrombus formation is induced in the rupture-prone plaques of WHHLMI rabbits by administration of additional triggering factors, and could provide a novel means for developing new therapies.
影响因子：
158.5
作者：
GOLDSTEIN, JL;KITA, T;BROWN, MS
通讯作者：
BROWN, MS