Rapid fabrication of microfluidic paper-based analytical devices by microembossing
Rapid fabrication of microfluidic paper-based analytical devices by microembossing
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DOI：
10.1016/j.snb.2018.12.004
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发表时间：
2019-03-15
影响因子：
8.4
通讯作者：
Wang, Yu
中科院分区：
文献类型：
--
作者：
Juang, Yi-Je;Chen, Po-Sheng;Wang, Yu
在这项研究中，制造微流控纸基分析器件（μ PAD）的微压印。与文献中描述的压花方法不同，对滤纸进行压花，使得形成突出结构，该突出结构随后在加热滤纸背面的蜡之后变成通道。发现当使用Whatman 3号滤纸时，压花压力需要大于50 kg/cm（2），同时使用最小2 mm宽的通道，并且蜡加热时间范围为15至45 s，以便获得具有重复性和一致性结果的可靠mu PAD。此外，不需要疏水性材料作为背侧支撑体。使用制造的μ PAD证明了葡萄糖检测，并且在5和50 mM葡萄糖浓度之间获得线性关系。利用所提出的方法，制造μ PAD的处理时间可以减少在大约1分钟内。
In this study, fabrication of microfluidic paper based analytical devices (mu PADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm(2) in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable mu PAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the mu PADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating mu PADs can be reduced within approximately 1 min.