Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model
Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model
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DOI：
10.1016/j.jhsa.2006.03.024
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发表时间：
2006-09-01
影响因子：
1.9
通讯作者：
Pilla, Arthur A.
中科院分区：
文献类型：
--
作者：
Strauch, Berish;Patel, Mitesh K.;Pilla, Arthur A.
目的：观察脉冲电磁场对大鼠跟腱断裂修复后3周生物力学强度的影响。方法：在一项前瞻性、随机、双盲、安慰剂对照研究中，对这种非侵入性方式进行了测试，以评估特定的非侵入性射频脉冲电磁场信号对大鼠模型横断后21天肌腱拉伸强度的影响。结果：在接受PMF暴露的动物中，与未受刺激的对照动物相比，在横断和修复后3周，大鼠跟腱修复部位的拉伸强度增加了69%。结论：在该动物模型中，电磁场的应用可以增强参与组织愈合的生长因子级联中的Ca2+结合，从而显著增加修复部位的拉伸强度。如果类似的效果发生在人类身上，康复可以更早开始，并且在术后早期发生粘连或肌腱断裂的风险可以降低。
Purpose: To examine the effect of pulsing electromagnetic fields on the biomechanic strength of rat Achilles' tendons at 3 weeks after transection and repair.Methods: This noninvasive modality was tested in a prospective, randomized, double-blinded, placebo-controlled study to evaluate the effect of a specific noninvasive radiofrequency pulsed electromagnetic field signal on tendon tensile strength at 21 days post transection in a rat model.Results: In the animals receiving PMF exposure, an increase in tensile strength of up to 69% was noted at the repair site of the rat, Achilles' tendon at 3 weeks after transection and repair compared with nonstimulated control animals.Conclusions: The application of electromagnetic fields, configured to enhance Ca2+ binding in the growth factor cascades involved in tissue healing, achieved a marked increase of tensile strength at the repair site in this animal model. If similar effects occur in humans, rehabilitation could begin earlier and the risk of developing adhesion's or rupturing the tendon in the early postoperative period could be reduced.