Resting state fMRI studies in SPG4-linked hereditary spastic paraplegia
Resting state fMRI studies in SPG4-linked hereditary spastic paraplegia
复制标题
SPG4相关遗传性痉挛性截瘫的静息态功能磁共振成像研究
DOI：
10.1016/j.jns.2017.10.048
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发表时间：
2018-01-15
影响因子：
4.4
通讯作者：
Shen, Lu
中科院分区：
文献类型：
--
作者：
Liao, Xinxin;Huang, Mufang;Shen, Lu
目的：本研究旨在探讨痉挛性截瘫4型（spastic parapleg 4 type 4，SPG 4）患者脑自发活动的功能改变及其与痉挛严重程度的关系。方法：12例SPG 4患者和10例健康对照者行静息态功能磁共振成像（rs-fMRI）。结果：与正常对照组相比，SPG 4患者额内侧上级回的低频波动幅度（ALFF）和区域均匀性（ReHo）值显著降低。ALFF值在患者组左侧额回较低，右侧中央前回和上级额回较高。患者右侧中央前体肌ALFF值增加与痉挛性截瘫评定量表（SPRS）评分呈负相关。连接性研究表明，SPG 4患者有一个增加FC之间的左额中回左中眶额回，和对减少FC。结论：我们的研究结果证实，基线区域神经活动和区域间连接改变在许多脑区的SPG 4患者，某些变化与疾病的严重程度，提供潜在的诊断标志物SPG 4。
Objective: The study aimed to investigate the functional alterations of spontaneous brain activity in patients with spastic paraplegia type 4 (SPG4), and the relationship with the severity of spasticity.Methods: Twelve patients with SPG4 and ten healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI). Amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to characterize regional neural function, and functional connectivity (FC) was used to evaluate the functional integration of the brain network.Results: Compared to healthy controls, patients with SPG4 exhibited significantly decreased ReHo values in the medial superior frontal gyrus. ALFF values were lower in left insula and higher in right precentral and superior frontal gyrus of the patient group. Increased ALFF values in the right precentral gyms negatively correlated with Spastic Paraplegia Rating Scale (SPRS) scores in the patients. The connectivity study showed that the SPG4 patients had one increased FC between the left middle frontal gyms to the left middle orbitofrontal gyrus, and pairs of decreased FC.Conclusions: Our findings confirm that the baseline regional neural activity and interregional connectivity are altered in many brain regions in patients with SPG4, and certain changes are correlated with disease severity, providing potential diagnostic markers for SPG4.