Resolution of 1-cyclohexylethylamine via diastereomeric salt formation with enantiopure 2-phenylacetic acids
Resolution of 1-cyclohexylethylamine via diastereomeric salt formation with enantiopure 2-phenylacetic acids
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DOI：
10.1016/j.tetasy.2006.05.010
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发表时间：
2006-06-19
影响因子：
--
通讯作者：
Hirayama, Noriaki
中科院分区：
文献类型：
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作者：
Sakai, Kenichi;Yokoyama, Masami;Hirayama, Noriaki
研究了1-环己基乙胺-1与对映体2-苯乙酸通过非对映异构体成盐拆分的方法。(R)-2-甲氧基-2-苯基乙酸3和(S)-2-苯丙酸5是获得单一对映体(S)-1的有效拆分剂(拆分率分别为48%和52%)。(C)2006年，爱思唯尔有限公司出版。
The resolution of 1-cyclohexylethylamine 1 with enantiopure 2-phenylacetic acids via diastereomeric salt formation was investigated. (R)-2-Methoxy-2-phenylacetic acid 3 and the (S)-2-phenylpropionic acid 5 were found to be efficient resolving agents for obtaining the single enantiomer (S)-1 as the correspondingly less-soluble diastereomeric salt (resolution efficiency = 48% and 52%, respectively). (c) 2006 Published by Elsevier Ltd.