[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
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DOI：
10.1212/01.wnl.0000078192.95645.e6
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发表时间：
2003-09-09
期刊：
影响因子：
9.9
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
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作者：
Gerhard, A;Banati, RB;Brooks, DJ
小胶质细胞，脑内的巨噬细胞，结合（R）-PK 11195时，神经元损伤激活。作者使用[C-11]（R）-PK 11195 PET定位多系统萎缩（MSA）患者体内小胶质细胞活化。[C-11]（R）-PK 11195结合增加主要见于背外侧前额叶皮质、壳核、苍白球、脑桥和黑质，反映了MSA中神经病理学变化的已知分布。[C-11]（R）-PK 11195 PET提供了疾病活动的指标，因此可用于表征MSA的体内神经病理学。
Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [C-11](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [C-11](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [C-11](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.