Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer
Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer
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DOI：
10.1097/mnm.0b013e32834209b5
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发表时间：
2011-06-01
影响因子：
1.5
通讯作者：
Nishiyama, Yoshihiro
中科院分区：
文献类型：
--
作者：
Kameyama, Reiko;Yamamoto, Yuka;Nishiyama, Yoshihiro
目的应用正电子发射断层扫描（PET）技术检测胃肠道肿瘤组织中平衡型核苷转运蛋白1（ENT 1）和胸苷激酶1（TK 1）信使核糖核酸（mRNA）的表达，探讨胃肠道肿瘤摄取3 '-脱氧-3'-氟-18-氟胸苷（FLT）的机制。肿瘤病变被确定为局灶性摄取增加的区域，超过周围正常组织。对于半定量分析，计算最大标准化摄取值（SUV）。结果胃肠道癌组织中，仅1例胃癌灶性摄取FLT增强。胃肠道癌的平均（+/-标准差）FLT SUV为5.48 +/- 1.87。FLT SUV与ENT 1 mRNA表达无明显相关性（P=0.90）。FLT SUV与TK 1 mRNA表达呈显著相关（P
Purpose We examined equilibrative nucleoside transporter-1 (ENT1) and thymidine kinase-1 (TK1) messenger ribonucleic acid (mRNA) expressions in cancer tissue samples to elucidate the mechanism of 3'-deoxy-3'-F-18-fluorothymidine (FLT) uptake by positron emission tomography (PET) scan in gastrointestinal cancer.Methods A total of 21 patients with newly diagnosed gastrointestinal cancer were examined with FLT PET. Tumor lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated. The expressions of ENT1 and TK1 in cancer tissue samples were compared with that of FLT SUV.Results Of all gastrointestinal cancer lesions only one gastric cancer showed focally increased uptake of FLT PET. The mean (+/- standard deviation) FLT SUV in gastrointestinal cancer was 5.48 +/- 1.87. There was no significant correlation between FLT SUV and ENT1 (P=0.90) mRNA expression. There was a significant correlation between FLT SUV and TK1 mRNA expression (P