The Characteristics of Power Spectral Density in Bipolar Disorder at the Resting State
The Characteristics of Power Spectral Density in Bipolar Disorder at the Resting State
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DOI：
10.1177/15500594211050487
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发表时间：
2021-10
影响因子：
2
通讯作者：
Masakazu Sunaga;Y. Takei;Yutaka Kato;Minami Tagawa;Tomohiro Suto;N. Hironaga;N. Sakurai;M. Fukuda
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文献类型：
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作者：
Masakazu Sunaga;Y. Takei;Yutaka Kato;Minami Tagawa;Tomohiro Suto;N. Hironaga;N. Sakurai;M. Fukuda
双相情感障碍是一种常见的精神疾病，但其病理生理机制尚未完全阐明。目前的研究重点是其电生理特性，特别是功率谱密度（PSD）。本文收集了21例BD患者和22例健康对照者的静息状态睁眼脑磁图数据。根据各频段（δ: 1-3 Hz, θ: 4-7 Hz, α: 8-12 Hz，低β: 13-19 Hz，高β: 20-29 Hz， γ: 30-80 Hz）的源重构波形计算全脑PSD。我们使用Mann-Whitney秩检验比较健康组和患者组在每个频带的标记顶点上的PSD值，以检验显著不同的PSD与临床测量之间的关系。BD患者的PSD在较低频段显著降低，主要在默认模式网络（DMN）区域（双侧内侧前额叶、双侧楔前叶、左侧下顶叶和右侧颞叶皮层的α波段）和突出网络区域（SAL；左前岛[AI]在δ波段，前扣带皮层在θ波段，右侧AI在α波段）。低β和高β时PSD无显著差异。PSD与年龄或其他临床量表无关。DMN和SAL的psd在δ、θ和α波段均有改变。这些改变通过干扰自我参照的心理活动和在默认模式和额顶叶网络之间切换而导致双相障碍的易感性。
Bipolar disorder (BD) is a common psychiatric disorder, but its pathophysiology is not fully elucidated. The current study focused on its electrophysiological characteristics, especially power spectral density (PSD). Resting state with eyes opened magnetoencephalography data were collected from 21 patients with BD and 22 healthy controls. The whole brain's PSD was calculated from source reconstructed waveforms at each frequency band (delta: 1-3 Hz, theta: 4-7 Hz, alpha: 8-12 Hz, low beta: 13-19 Hz, high beta: 20-29 Hz, and gamma: 30-80 Hz). We compared PSD values on the marked vertices at each frequency band between healthy and patient groups using a Mann-Whitney rank test to examine the relationship between significantly different PSD and clinical measures. The PSD in patients with BD was significantly decreased in lower frequency bands, mainly in the default mode network (DMN) areas (bilateral medial prefrontal cortex, bilateral precuneus, left inferior parietal lobe, and right temporal cortex in the alpha band) and salience network areas (SAL; left anterior insula [AI] at the delta band, anterior cingulate cortex at the theta band, and right AI at the alpha band). No significant differences in PSD were observed at low beta and high beta. PSD was not correlated with age or other clinical scales. Altered PSDs of the DMN and SAL were observed in the delta, theta, and alpha bands. These alterations contribute to the vulnerability of BD through the disturbance of self-referential mental activity and switching between the default mode and frontoparietal networks.