Procoagulant microparticles: "Criminal partners" in atherothrombosis and deleterious cellular exchanges
Procoagulant microparticles: "Criminal partners" in atherothrombosis and deleterious cellular exchanges
复制标题
DOI：
10.1159/000093538
复制
发表时间：
2006-01-01
影响因子：
--
通讯作者：
Freyssinet, Jean-Marie
中科院分区：
文献类型：
--
作者：
Morel, Olivier;Toti, Florence;Freyssinet, Jean-Marie
促凝血微粒（MP）是动脉粥样硬化血栓形成过程中血管细胞损伤的重要标志。在健康个体的血流中以低浓度检测，促凝血微粒水平升高是大多数心血管危险因素的特征。循环MP支持细胞串扰，导致血管炎症、内皮功能障碍、白细胞粘附和募集，可能导致斑块生长，并连续发生局部血栓形成和血管运动改变。在斑块内，凋亡单核细胞和平滑肌细胞释放的MP是斑块血栓形成的主要决定因素，主要通过组织因子（TF）活性的存在。除了这种促凝血作用外，截留的MP还可能通过多种途径导致斑块易损性，包括血管生成、细胞外基质蛋白水解、炎症细胞募集、平滑肌细胞和内皮细胞凋亡。长期以来被认为足以在斑块破裂后启动凝血，分配给斑块结合TF的作用在宏观尺度上似乎不现实，血栓的快速生长可能涉及通过循环MP输送的血源性TF。作为动脉粥样硬化疾病关键步骤的参与者，MP现在可以被视为急性缺血综合征的“犯罪伙伴”。版权所有（c）2006 S. Karger AG，巴塞尔。
Procoagulant microparticles (MP) constitute valuable hallmarks of vascular cell damage at the crossroad of atherothrombosis processes. Detectable at low concentrations in the blood flow of healthy individuals, elevated levels of procoagulant microparticles are characteristic features of most cardiovascular risk factors. Circulating MP support cellular cross-talk leading to vascular inflammation, endothelial dysfunction, leukocyte adhesion and recruitment possibly contributing to plaque growth with consecutive development of local thrombosis and altered vasomotion. Within the plaque, MP shed by apoptotic monocytes and smooth muscle cells are major determinant of plaque thrombogenicity mainly through the presence of tissue factor (TF) activity. Besides this procoagulant potential, trapped MP could contribute to plaque vulnerability through multiple pathways including angiogenesis, extracellular matrix proteolysis, recruitment of inflammatory cells, smooth muscle cell and endothelial apoptosis. Having long been considered sufficient to initiate coagulation following plaque disruption, the role assigned to plaque-bound TF does not appear physically realistic at a macroscopic scale, the swift growth of the thrombus probably involving bloodborne TF conveyed by circulating MP. As participants in crucial steps of atherosclerotic disease, MP can now be viewed as "partners in crime" in acute ischemic syndromes. Copyright (c) 2006 S. Karger AG, Basel.