SO2 AND ITS METABOLITE - EFFECTS ON MAMMALIAN EGG CHROMOSOMES
SO2 AND ITS METABOLITE - EFFECTS ON MAMMALIAN EGG CHROMOSOMES
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DOI：
10.1016/0013-9351(75)90052-3
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发表时间：
1975-01-01
影响因子：
8.3
通讯作者：
DUCAYEN, MB
中科院分区：
文献类型：
--
作者：
JAGIELLO, GM;LIN, JS;DUCAYEN, MB
二氧化硫作为一种空气污染物的普遍存在，以及有关气体及其血液代谢产物对DNA和染色体影响的报道，促使人们研究对哺乳动物卵母细胞可能的诱变作用。利用体外和体内系统，对小鼠、绵羊和奶牛卵母细胞进行了检查，以寻找减数分裂中结构或数量损伤的细胞学证据。在M1和M2期观察到的片段化和重排，以及在体外观察到的分裂后期滞后，是染色体异常的典型病因，必须加以考虑，特别是在污染地区，涉及母羊和母牛的胎儿丢失灶。
The ubiquity of sulfur dioxide as an air pollutant combined with reports of effects of the gas and its blood metabolite on DNA and chromosomes, prompted a study of possible mutagen action on mammalian oocytes. Utilizingin vitroandin vivosystems, mouse, ewe, and cow oocytes were examined for cytologic evidence of structural or numerical damage in meiosis. Fragmentation with rearrangement seen at M1and M2and anaphase lagging seenin vitroin each species are classically known to be etiologic in chromosome abnormalities and must be considered, especially in contaminated areas with foci of fetal loss involving ewe and cow.