Time-resolved Vessel-selective Digital Subtraction MR Angiography of the Cerebral Vasculature with Arterial Spin Labeling
Time-resolved Vessel-selective Digital Subtraction MR Angiography of the Cerebral Vasculature with Arterial Spin Labeling
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DOI：
10.1148/radiol.10092333
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发表时间：
2010-11-01
期刊：
影响因子：
19.7
通讯作者：
Alsop, David C.
中科院分区：
文献类型：
--
作者：
Robson, Philip M.;Dai, Weiying;Alsop, David C.
目的：展示一种动脉自旋标记(ASL)磁共振(MR)血管成像技术，该技术覆盖整个脑血管，获得与X射线数字减影血管成像(DSA)相似的透明背景、时间分辨的血流动力学和血管特异性信息，无需使用外源性造影剂。材料和方法：这项符合HIPAA标准的研究事先获得机构审查委员会的批准和书面知情同意，12名健康志愿者(女性5名，男性7名；年龄21-62岁；平均年龄28岁)接受了成像。应用可变标记持续时间获取血流动力学信息的ASL技术和血管选择性脉冲-连续ASL技术进行了测试。不同血管节段的感兴趣区域信号强度被跨受试者平均，并用于图像的定量比较。作为对照，在Willis环进行标准飞行时间(TOF)采集。结果：流入的时间分辨率为200 ms，显示从Willis环远端到中脑深部的大脑中动脉连续节段的动脉传输时间分别为750、950和1100 ms。选择性标记导致对侧血管比被标记血管平均抑制8倍。88秒体积采集(分别为60+/-15[标准差]和57+/-15)和11秒单投影采集(分别为19+/-5和17+/-5)获得的最大强度投影图像的信噪比和对比度噪声比与标准TOF采集相当，后者的成像时间长2.7倍，像素面积低2.6倍。结论：ASL血管造影可获得与X线片DSA相似的血流动力学血管特异性信息。(C)RSNA，2010年
Purpose: To demonstrate an arterial spin-labeling (ASL) magnetic resonance (MR) angiographic technique that covers the entire cerebral vasculature and yields transparent-background, time-resolved hemodynamic, and vessel-specific information similar to that obtained with x-ray digital subtraction angiography (DSA) without the use of exogenous contrast agents.Materials and Methods: Prior institutional review board approval and written informed consent were obtained for this HIPAA-compliant study in which 12 healthy volunteers (five women, seven men; age range, 21-62 years; average age, 28 years) underwent imaging. An ASL technique in which variable labeling durations are used to acquire hemodynamic inflow information and a vessel-selective pulsed-continuous ASL technique were tested. Region-of-interest signal intensities in various vessel segments were averaged across subjects and used to quantitatively compare images. For comparison, a standard time of flight (TOF) acquisition was performed in the circle of Willis.Results: Inflow temporal resolution of 200 msec was demonstrated, revealing arterial transit times of 750, 950, and 1100 msec to consecutive segments of the middle cerebral artery from distal to the circle of Willis to deep regions of the midbrain. Selective labeling resulted in an average of eightfold suppression of contralateral vessels relative to the labeled vessel. Signal-to-noise ratios and contrast-to-noise ratios on maximum intensity projection images obtained with 88-second volumetric acquisitions (60 +/- 15 [standard deviation] and 57 +/- 15, respectively) and 11-second single-projection acquisitions (19 +/- 5 and 17 +/- 5, respectively) were comparable with standard TOF acquisitions, in which a 2.7-fold longer imaging duration for a 2.6-fold lower pixel area was used. Normal variations of the vasculature were identified with ASL angiography.Conclusion: ASL angiography can be used to acquire hemodynamic vessel-specific information similar to that obtained with x-ray DSA. (C) RSNA, 2010