Polypharmacy and drug use in elderly Danish cancer patients during 1996 to 2006
Polypharmacy and drug use in elderly Danish cancer patients during 1996 to 2006
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DOI：
10.1016/j.jgo.2011.09.001
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Hallas, J.
中科院分区：
文献类型：
--
作者：
Jorgensen, T. L.;Herrstedt, J.;Hallas, J.
背景：老年人经常接触多种药物，定义为同时使用多种药物。然而，老年癌症患者的药物使用数据有限。本研究的目的是描述年龄 >= 70 岁的癌症患者的药物使用和多重用药情况，并描述他们在癌症诊断之前和之后的药物使用模式。方法：对 1996 年至 2006 年丹麦菲英省（人口 480,000）所有癌症病例进行基于人群的病例对照研究。数据收集自丹麦癌症登记处和欧登塞药物流行病学数据库。使用条件逻辑回归来比较病例和对照的药物使用情况。结果：我们确定了 24,808 名癌症病例和 99,299 名对照。其中，47% 的年龄>= 70 岁。诊断时，35% 的老年病例每天使用≥ 5 种药物，而对照组为 27%，OR 1.76（95% CI 1.66-1.86），并且早在癌症诊断前 18 个月，药物使用率就显着较高。特别是，在癌症诊断前六个月，镇痛药、抑酸药和抗生素的使用显着增加。在研究期间，诊断时的平均每日药物使用量有所增加。结论：新诊断的老年癌症患者比背景人群使用更多的药物。在癌症诊断前的最后六个月，药物使用显着增加。这可能表明患者在诊断前症状负担增加，并可能作为全科医生的警告信号。 (C) 2011 Elsevier Ltd. 保留所有权利。
Background: Elderly people are frequently exposed to polypharmacy defined as the simultaneous use of multiple drugs. However, data on drug use among elderly cancer patients are limited. The aims of this study were to describe drug use and polypharmacy in cancer patients aged >= 70 years and to describe their drug usage pattern prior to and following the cancer diagnosis.Methods: Population-based case-control study of all incident cancer cases in the Danish province of Funen (population 480,000) from 1996 to 2006. Data were collected from the Danish Cancer Registry and the Odense Pharmacoepidemiologic Database. Conditional logistic regression was used to compare drug use in cases and controls.Results: We identified 24,808 cancer cases and 99,299 controls. Of these, 47% were aged >= 70 years. At diagnosis, 35% of elderly cases used >= 5 drugs daily compared with 27% of controls, OR 1.76 (95% CI 1.66-1.86), and drug use was significantly higher as early as 18 months prior to the cancer diagnosis. In particular, use of analgesics, acid-suppressing drugs, and antibiotics increased markedly six months preceding cancer diagnosis. mean daily drug use at diagnosis increased during the study period.Conclusion: Newly diagnosed elderly cancer patients use more drugs than the background population. Drug use increased markedly the last six months prior to the cancer diagnosis. This could suggest an increased symptom burden in patients prior to diagnosis and might serve as a warning signal for general practitioners. (C) 2011 Elsevier Ltd. All rights reserved.