The contribution of reoxygenation to ischemic brain damage.
The contribution of reoxygenation to ischemic brain damage.
复制标题
再氧合对缺血性脑损伤的贡献。
DOI：
10.1038/jcbfm.1991.166
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Sarvary,E
中科院分区：
文献类型：
--
作者：
HalseyJr,JH;Conger,KA;Garcia,JH;Sarvary,E
本研究检验了缺血后再灌注水平影响神经元坏死严重程度的假设。在大鼠中，通过长期植入铂电极，在四个皮质部位监测组织Po2%作为血流（复氧）指数。全脑缺血20分钟后再给氧30分钟。控制复氧水平，以维持一个或多个皮层电极的Po2几乎恒定。对7只大鼠19个电极部位400 μm范围内的组织进行组织学评价。复氧水平与神经元损伤程度呈正相关。神经元周透明晕形成可能代表星形胶质细胞足突肿胀，与复氧水平呈负相关。这项研究表明，缺血性神经元损伤加重增加复氧，但神经元周围肿胀，证明了晕形成，有所改善。
This study examined the hypothesis that the level of postischemic reperfusion affects the severity of the resulting neuronal necrosis. In rats, tissue Po2% was monitored as an index of flow (reoxygenation) at four cortical sites by chronically implanted platinum electrodes. Twenty minutes of total global cerebral ischemia was followed by 30 min of reoxygenation. The level of reoxygenation was controlled to maintain the Po2nearly constant at one or more of the cortical electrodes. Tissue from within 400 μm of each of 19 electrode sites among seven rats was evaluated histologically. There was a positive correlation between reoxygenation level and severity of neuronal damage. Perineuronal lucent halo formation, probably representing astrocyte foot process swelling, was negatively correlated with reoxygenation level. This study demonstrates that ischemic neuronal damage was aggravated by increased reoxygenation but that perineuronal swelling, as evidenced by halo formation, was somewhat ameliorated.